ArticleMolecular autism2013
Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk?
Article in Molecular autism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- [Early death and causes of death of patients with autism spectrum disorders: A systematic review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Pooled it
- Relationship of epilepsy on the linguistic-cognitive profile of children with ASD: A systematic review of the literature.Frontiers in psychology · 2023Pooled it
- Epilepsy in Autism: Prevalence and Associated Factors in a Large Inpatient Psychiatric Sample.Journal of autism and developmental disorders · 2025Article
- EEG Abnormalities and Phenotypic Correlates in Preschoolers with Autism Spectrum Disorder: A Single-Center Study.Journal of clinical medicine · 2025Article
- Autism Spectrum Disorder with Epilepsy: A Research Protocol for a Clinical and Genetic Study.Genes · 2023Article
- Article
- Article
- Sleep Disturbances in Children Affected by Autism Spectrum Disorder.Frontiers in psychiatry · 2022Article
- Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes.International journal of molecular sciences · 2021Review
- A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders.Annals of clinical and translational neurology · 2020Article
- Big data approaches to decomposing heterogeneity across the autism spectrum.Molecular psychiatry · 2019Review
- Clinical Management of Children and Adolescents with Neurofibromatosis Type 1 Like Phenotypes and Complex Behavioural Manifestations: A Multidisciplinary and Dimensional Approach.Case reports in psychiatry · 2019Article
- Article
- Effect of epilepsy on autism symptoms in Angelman syndrome.Molecular autism · 2018Article
- Role of Genetics in the Etiology of Autistic Spectrum Disorder: Towards a Hierarchical Diagnostic Strategy.International journal of molecular sciences · 2017Review
- Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse.Physiology & behavior · 2017Article
- Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study.BMC neurology · 2016Article
- Bidirectional association between autism spectrum disorder and epilepsy in child and adolescent patients: a population-based cohort study.European child & adolescent psychiatry · 2016Article
- Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis.Journal of autism and developmental disorders · 2016Article
- Autism and epilepsy: A population-based nationwide cohort study.Neurology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorders (ASD) and epilepsy frequently occur together. Prevalence rates are variable, and have been attributed to age, gender, comorbidity, subtype of pervasive developmental disorder (PDD) and risk factors. Recent studies have suggested disparate clinical and genetic settings depending on simplex or multiplex autism. The aim of this study was to assess: 1) the prevalence of epilepsy in multiplex autism and its association with genetic and non-genetic risk factors of major effect, intellectual disability and gender; and 2) whether autism and epilepsy cosegregate within multiplex autism families.
methodsWe extracted from the Autism Genetic Resource Exchange (AGRE) database (n = 3,818 children from 1,264 families) all families with relevant medical data (n = 664 children from 290 families). The sample included 478 children with ASD and 186 siblings without ASD. We analyzed the following variables: seizures, genetic and non-genetic risk factors, gender, and cognitive functioning as assessed by Raven's Colored Progressive Matrices (RCPM) and Vineland Adaptive Behavior Scales (VABS).
resultsThe prevalence of epilepsy was 12.8% in cases with ASD and 2.2% in siblings without ASD (P <10-5). With each RCPM or VABS measure, the risk of epilepsy in multiplex autism was significantly associated with intellectual disability, but not with gender. Identified risk factors (genetic or non-genetic) of autism tended to be significantly associated with epilepsy (P = 0.052). When children with prematurity, pre- or perinatal insult, or cerebral palsy were excluded, a genetic risk factor was reported for 6/59 (10.2%) of children with epilepsy and 12/395 (3.0%) of children without epilepsy (P = 0.002). Finally, using a permutation test, there was significant evidence that the epilepsy phenotype co-segregated within families (P <10-4).
conclusionsEpilepsy in multiplex autism may define a different subgroup in terms of clinical characteristics and genetic risk.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.