ArticleMobile DNA2013
Distinctive patterns of epigenetic marks are associated with promoter regions of mouse LINE-1 and LTR retrotransposons.
Article in Mobile DNA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Major waves of H2A.Z incorporation during mouse oogenesis and preimplantation embryo development.Nature communications · 2025Article
- Foxg1 bimodally tunes L1-mRNA and -DNA dynamics in the developing murine neocortex.Development (Cambridge, England) · 2024Article
- Competition for H2A.Z underlies the developmental impacts of repetitive element de-repression.Development (Cambridge, England) · 2023Article
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- Analysis of epigenetic features characteristic of L1 loci expressed in human cells.Nucleic acids research · 2022Article
- Transposable Elements and Stress in Vertebrates: An Overview.International journal of molecular sciences · 2021Review
- What impact does oocyte vitrification have on epigenetics and gene expression?Clinical epigenetics · 2020Review
- Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations.Nature communications · 2017Article
- Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Identification of recurrent combinatorial patterns of chromatin modifications at promoters across various tissue types.BMC bioinformatics · 2016Article
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.Environmental research · 2016Article
- The transposable element environment of human genes is associated with histone and expression changes in cancer.BMC genomics · 2016Article
- Restricting retrotransposons: a review.Mobile DNA · 2016Review
- Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer.BMC cancer · 2014Article
- Exploiting the power of LINE-1 retrotransposon mutagenesis for identification of genes involved in embryonic stem cell differentiation.Stem cell reviews and reports · 2014Article
- LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?Frontiers in genetics · 2014Article
- Response of transposable elements to environmental stressors.Mutation research. Reviews in mutation researchReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe long terminal repeat (LTR) retrotransposons and the non-LTR retrotransposons (LINE-1 or L1) make up more than one-third of the mouse genome. Because of their abundance, the retrotransposons are the major players in genomic structure and function. While much attention has been focused on the biology of retrotransposons, little is known about the chromatin structure of these elements or the potential role of epigenetic marks on the regulation of retrotransposon expression.
findingsUsing sequential chromatin immunoprecipitation analysis, we analyzed the cohabitation of several post-translational histone modifications in the promoter regions of mouse L1 and LTR retrotransposons. We show here that the variant histone H2A.Z selectively present in L1 promoters. Notably, H2A.Z and trimethylated histone H3 (H3K9me3) co-localize in the same genomic location of the L1 promoter along with heterochromatin-binding protein HP1α. In contrast, MmERV and intracisternal A-particle (IAP) classes of LTR promoters are enriched with core histone H2A and heterochromatic trimethylated histone H4 (H4K20me3). These distinctive patterns of chromatin modifications are relatively consistent irrespective of cell type.
conclusionsChromatin structure regulates the expression of retrotransposons. LINE-1 elements are associated with H2A.Z and HP1α-containing constitutive heterochromatin, while the LTR elements are enriched with H2A and the H4K20me3-type of facultative heterochromatin. Our findings demonstrate that different epigenetic mechanisms operate in the mouse genome to silence different classes of retrotransposons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.