ArticleBioMed research international2013
A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Evaluation of intra-articular injection of collagen-elastin hydrogel microparticles for managing osteoarthritis-associated elbow pain in dogs: a double-blind, positive-controlled clinical trial.Frontiers in veterinary science · 2026Trial
- A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis.BMC veterinary research · 2017Trial
- Effects of single and combination dosage regimens of ketorolac and dexmedetomidine on allodynia and nociception in rat model of osteoarthritis: an animal multi-group trial.BMC anesthesiology · 2026Article
- From dyadic deco-construction to reco-construction: a framework for the human-osteoarthritic dog relationship.Frontiers in veterinary science · 2026Review
- Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine.Animal models and experimental medicine · 2024Review
- Evaluation of the comparative efficacy of green lipped mussel plus krill oil extracts (EAB-277),Frontiers in veterinary science · 2024Article
- Evaluation of Four Clinical Metrology Instruments for the Assessment of Osteoarthritis in Dogs.Animals : an open access journal from MDPI · 2022Article
- Effect of a single intra-articular administration of stanozolol in a naturally occurring canine osteoarthritis model: a randomised trial.Scientific reports · 2022Article
- Three-dimensional kinematic evaluation of Tightrope CCL in a canineCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2019Article
- Models of osteoarthritis: the good, the bad and the promising.Osteoarthritis and cartilage · 2019Review
- Krogh's principle for musculoskeletal physiology and pathology.Journal of musculoskeletal & neuronal interactions · 2018Article
- Peak vertical force in a stabilized canine cranial cruciate deficient stifle model: A one-year follow-up.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Article
- Evaluation of the Curative Effect of Umbilical Cord Mesenchymal Stem Cell Therapy for Knee Arthritis in Dogs Using Imaging Technology.Stem cells international · 2018Article
- Expression of tissue inhibitor of metalloproteinases-1 and B-cell lymphoma-2 in the synovial membrane in patients with knee osteoarthritis.Experimental and therapeutic medicine · 2018Article
- Determination of knee cartilage volume and surface area in beagle dogs: a pilot study.Journal of experimental orthopaedics · 2017Article
- Functional outcome measures in a surgical model of hip osteoarthritis in dogs.Journal of experimental orthopaedics · 2016Article
- Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model.Arthritis research & therapy · 2016Article
- Animal models of osteoarthritis: classification, update, and measurement of outcomes.Journal of orthopaedic surgery and research · 2016Review
- Establishment of a rat model for osteoarthritis resulting from anterior cruciate ligament rupture and its significance.Experimental and therapeutic medicine · 2015Article
- Kinetic measurements of gait for osteoarthritis research in dogs and cats.The Canadian veterinary journal = La revue veterinaire canadienne · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.
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