ReviewInternational journal of endocrinology2013
Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity.
Review in International journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 4 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- The interplay between the adrenergic system and obesity: a systematic review.International journal of obesity (2005) · 2025Pooled it
- Association Between Anthropometric Risk Factors and Metabolic Syndrome Among Adults in India: A Systematic Review and Meta-Analysis of Observational Studies.Preventing chronic disease · 2022Pooled it
- The Prevalence of Metabolic Syndrome in Ethiopian Population: A Systematic Review and Meta-analysis.Journal of obesity · 2020Pooled it
- Identification of a 1p21 independent functional variant for abdominal obesity.International journal of obesity (2005) · 2019Pooled it
- Rosiglitazone influences adipose tissue distribution without deleterious impact on heart rate variability in coronary heart disease patients with type 2 diabetes.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Trial
- Endocrine determinants of changes in insulin sensitivity and insulin secretion during a weight cycle in healthy men.PloS one · 2015Trial
- Epigenetic signatures of cardiometabolic risk in men: accelerated aging and differential methylation replicated across cohorts.Clinical epigenetics · 2026Article
- Computer-aided ligand identification of capsaicinoids and their potential functions in metabolic diseases.Molecular diversity · 2026Article
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Prevalence, component patterns, and lifestyle correlates of metabolic syndrome among civil servants undergoing routine health examinations in Guangzhou, China: a cross-sectional study.Frontiers in public health · 2026Article
- Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity.Scientific reports · 2025Article
- Interaction Between theInternational journal of molecular sciences · 2025Article
- Mechanisms Linking Obesity with Non-Alcoholic Fatty Liver Disease (NAFLD) and Cardiovascular Diseases (CVDs)-The Role of Oxidative Stress.Current issues in molecular biology · 2025Review
- Obesity Paradox in Takotsubo Syndrome Among Septic ICU Patients: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Metabolic improvement after exercise training in children with obesity: Possible role of the six-minute walking test.PloS one · 2025Article
- Trauma and Posttraumatic Stress Disorder as Important Risk Factors for Gestational Metabolic Dysfunction.American journal of perinatology · 2024Review
- Anthropometric Predictors of Heart Rate Variability in Overweight Individuals: A Comparative Study.Cureus · 2024Article
- Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management.Biomedicines · 2024Review
- Obesity: An Impact with Cardiovascular and Cerebrovascular Diseases.Indian journal of clinical biochemistry : IJCB · 2024Review
- Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of the metabolic syndrome has increased worldwide over the past few years. Sympathetic nervous system overactivity is a key mechanism leading to hypertension in patients with the metabolic syndrome. Sympathetic activation can be triggered by reflex mechanisms as arterial baroreceptor impairment, by metabolic factors as insulin resistance, and by dysregulated adipokine production and secretion from visceral fat with a mainly permissive role of leptin and antagonist role of adiponectin. Chronic sympathetic nervous system overactivity contributes to a further decline of insulin sensitivity and creates a vicious circle that may contribute to the development of hypertension and of the metabolic syndrome and favor cardiovascular and kidney disease. Selective renal denervation is an emerging area of interest in the clinical management of obesity-related hypertension. This review focuses on current understanding of some mechanisms through which sympathetic overactivity may be interlaced to the metabolic syndrome, with particular regard to the role of insulin resistance and of some adipokines.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.