ArticleTheScientificWorldJournal2013
Cytotoxic and apoptotic effects of different extracts of Artemisia turanica Krasch. on K562 and HL-60 cell lines.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Anti-proliferative activity of Artemisia marschalliana on cancerous cell lines.BMC complementary medicine and therapies · 2023Article
- Cytotoxic Activity and Phytochemical Analysis ofIranian journal of pharmaceutical research : IJPR · 2022Article
- Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells.Molecular biology reports · 2020Article
- Isolation of Two Isochlorogenic Acid Isomers from Phenolic Rich Fraction ofIranian journal of pharmaceutical research : IJPR · 2020Article
- Celecoxib, indomethacin, and ibuprofen prevent 6-hydroxydopamine-induced PC12 cell death through the inhibition of NFκB and SAPK/JNK pathways.Iranian journal of basic medical sciences · 2019Article
- Article
- Cytotoxic Activity of Thirteen Endemic and Rare Plants from Chaharmahal and Bakhtiari Province in Iran.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Cytotoxic Properties of Three Isolated Coumarin-hemiterpene Ether Derivatives fromIranian journal of pharmaceutical research : IJPR · 2017Article
- Phytochemical Content and Pharma-Nutrition Study onOxidative medicine and cellular longevity · 2016Article
- In vitro cytotoxicity of Artemisia vulgaris L. essential oil is mediated by a mitochondria-dependent apoptosis in HL-60 leukemic cell line.BMC complementary and alternative medicine · 2014Article
- A semipolar fraction of petroleum ether extract of Artemisia aucheri induces apoptosis and enhances the apoptotic response to doxorubicin in human neuroblastoma SKNMC cell line.Research in pharmaceutical sciencesArticle
- The mechanism of neuroprotective effect ofAvicenna journal of phytomedicineArticle
- The Protective Effect of Different Extracts of ThreePharmacognosy researchArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisia is an important genus of Iranian flora. Cytotoxic activities for some species of the genus have already been reported. In this study, we have investigated the cytotoxic effects of n-hexane, CH2Cl2, EtOAc, EtOH, and EtOH/H2O (1:1) extracts of A. turanica Krasch. on two human leukemic cancer cell lines (K562 and HL-60) and J774 as normal cells using alamarBlue (resazurin) assay. PI staining of the fragmented DNA and western blot analysis were used to evaluate the possible apoptotic effect of the extract. The CH2Cl2 extract of A. turanica showed the most antiproliferative effect on cancer cells among all tested extracts with IC50 values of 69 and 104 μ g/mL on K562 and HL-60 cells, respectively, whereas the normal cells were not affected significantly by this extract. Sub-G1 peak in the flow cytometry histogram of the cells treated with CH2Cl2 extract of A. turanica and cleavage of PARP protein confirmed the induction of apoptosis with CH2Cl2 extract. Taken together, the findings of the present work suggest the anticancer potential of CH2Cl2 extract of A. turanica on human leukemic cancer cell lines.
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