ArticleMediators of inflammation2013
The influence of oral bacteria on epithelial cell migration in vitro.
Article in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Multiple-layer mesh from electrospinnable amyloid‑like protein and their application in treating oral ulcer.Nature communications · 2026Article
- Longitudinal Characterization of Gingival Microbiota Following Periodontally Accelerated Osteogenic Orthodontics Surgery in Skeletal Class III Orthognathic Patients.International dental journal · 2026Article
- The Human Amniotic Membrane: A Rediscovered Tool to Improve Wound Healing in Oral Surgery.International journal of molecular sciences · 2025Review
- The intriguing strategies ofFrontiers in oral health · 2024Article
- Mucositis and Infection in Hematology Patients.International journal of molecular sciences · 2023Article
- The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation.Cancer science · 2022Article
- Oral Microbiota-Driven Cell Migration in Carcinogenesis and Metastasis.Frontiers in cellular and infection microbiology · 2022Review
- Oral-Gut Microbiome Axis in the Pathogenesis of Cancer Treatment-Induced Oral Mucositis.Frontiers in oral health · 2022Review
- Article
- The Bigger Picture: Why Oral Mucosa Heals Better Than Skin.Biomolecules · 2021Review
- Microbial changes in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients.Scientific reports · 2019Article
- KREAP: an automated Galaxy platform to quantify in vitro re-epithelialization kinetics.GigaScience · 2018Article
- Oral microbiota reduce wound healing capacity of epithelial monolayers, irrespective of the presence of 5-fluorouracil.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells.Journal of innate immunity · 2018Article
- Streptococcus salivarius MS-oral-D6 promotes gingival re-epithelialization in vitro through a secreted serine protease.Scientific reports · 2017Article
- Article
- Persistent Exposure toFrontiers in cellular and infection microbiology · 2017Article
- Human dental stem cells suppress PMN activity after infection with the periodontopathogens Prevotella intermedia and Tannerella forsythia.Scientific reports · 2016Article
- Epithelial cells from oral mucosa: How to cultivate them?Cytotechnology · 2016Article
- Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.BMC microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral ulcerations often arise as a side effect from chemo- and radiation therapy. In a previous clinical study, Porphyromonas gingivalis was identified as a positive predictor for oral ulcerations after hematopoetic stem cell transplantation, possibly incriminating P. gingivalis in delayed healing of the ulcerations. Therefore, it was tested whether P. gingivalis and its secreted products could inhibit the migration of oral epithelial cells in an in vitro scratch assay. To compare, the oral bacteria Prevotella nigrescens, Prevotella intermedia, Tannerella forsythia, and Streptococcus mitis were included. A standardized scratch was made in a confluent layer of human oral epithelial cells. The epithelial cells were challenged with bacterial cells and with medium containing secretions of these bacteria. Closure of the scratch was measured after 17 h using a phase contrast microscope. P. gingivalis, P. nigrescens, and secretions of P. gingivalis strongly inhibited cell migration. A challenge with 1000 heat-killed bacteria versus 1 epithelial cell resulted in a relative closure of the scratch of 25% for P. gingivalis and 20% for P. nigrescens. Weaker inhibitory effects were found for the other bacteria. The results confirmed our hypothesis that the oral bacteria may be involved in delayed wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.