ArticleDisease markers2013
Association of a FGFR-4 gene polymorphism with bronchopulmonary dysplasia and neonatal respiratory distress.
Article in Disease markers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms.Pediatric research · 2022Trial
- Hippo signaling pathway regulates branching morphogenesis of the fetal lung under hypoxia.Pediatric research · 2026Article
- FGF family in health and disease.Molecular biomedicine · 2026Review
- Association ofBiomedicines · 2025Article
- Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children.Scientific reports · 2024Article
- Association of the rs1966265 and rs351855Biomedicines · 2024Article
- Genetic and Biochemical Predictors of Neonatal Bronchopulmonary Dysplasia.Journal of pediatric genetics · 2022Article
- Verification of immunology-related genetic associations in BPD supports ABCA3 and five other genes.Pediatric research · 2022Article
- Polymorphisms of fibronectin-1 (rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655) are not associated with bronchopulmonary dysplasia in preterm infants.Molecular and cellular biochemistry · 2022Article
- Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function.Science (New York, N.Y.) · 2022Article
- Hedgehog signaling pathway gene variant influences bronchopulmonary dysplasia in extremely low birth weight infants.World journal of pediatrics : WJP · 2021Observational
- Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies.Disease models & mechanisms · 2021Review
- FGF/FGFR signaling in health and disease.Signal transduction and targeted therapy · 2020Review
- Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?Frontiers in medicine · 2020Article
- FGF Signaling in Lung Development and Disease: Human Versus Mouse.Frontiers in genetics · 2019Review
- FGF receptors control alveolar elastogenesis.Development (Cambridge, England) · 2017Article
- Functional FGFR4 Gly388Arg polymorphism contributes to oral squamous cell carcinoma susceptibility.Oncotarget · 2017Article
- Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia.The Journal of pediatrics · 2017Article
- Article
- Genetic predisposition to bronchopulmonary dysplasia.Seminars in perinatology · 2015Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchopulmonary dysplasia (BPD) is the most common chronic lung disease of premature birth, characterized by impaired alveolar development and inflammation. Pathomechanisms contributing to BPD are poorly understood. However, it is assumed that genetic factors predispose to BPD and other pulmonary diseases of preterm neonates, such as neonatal respiratory distress syndrome (RDS). For association studies, genes upregulated during alveolarization are major candidates for genetic analysis, for example, matrix metalloproteinases (MMPs) and fibroblast growth factors (FGFs) and their receptors (FGFR).
objectiveDetermining genetic risk variants in a Caucasian population of premature neonates with BPD and RDS. Methods. We genotyped 27 polymorphisms within 14 candidate genes via restriction fragment length polymorphism (RFLP): MMP-1, -2, -9, and -12, -16, FGF receptors 2 and 4, FGF-2, -3, -4, -7, and -18, Signal-Regulatory Protein α (SIRPA) and Thyroid Transcription Factor-1 (TTF-1).
resultsFive single nucleotide polymorphisms (SNPs) in MMP-9, MMP-12, FGFR-4, FGF-3, and FGF-7 are associated (P < 0.05) with RDS, defined as surfactant application within the first 24 hours after birth. One of them, in FGFR-4 (rs1966265), is associated with both RDS (P = 0.003) and BPD (P = 0.023).
conclusionrs1966265 in FGF receptor 4 is a possible genetic key variant in alveolar diseases of preterm newborns.
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