ArticleDisease markers2013
Is human papillomavirus associated with prostate cancer survival?
Article in Disease markers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Intratumoral Human Papillomavirus in Advanced Prostate Cancer: Systematic Review, Meta-Analysis, and Real-World Evidence from the Largest Cohort to Date.International journal of molecular sciences · 2026Pooled it
- Article
- Evaluation of human papillomavirus as a risk factor in prostate cancer pathogenesis.Discover oncology · 2025Review
- Does Human Papillomavirus Play a Causative Role in Prostate Cancer? A Systematic Review Using Bradford Hill's Criteria.Cancers · 2023Review
- A matched case-control study in Taiwan to evaluate potential risk factors for prostate cancer.Scientific reports · 2023Article
- Differential Microbial Signature Associated With Benign Prostatic Hyperplasia and Prostate Cancer.Frontiers in cellular and infection microbiology · 2022Article
- Evidence for a causal role by human papillomaviruses in prostate cancer - a systematic review.Infectious agents and cancer · 2020Review
- Expressional profiling and clinical relevance of RNase κ in prostate cancer: a novel indicator of favorable progression-free survival.Journal of cancer research and clinical oncology · 2018Article
- Association between human papillomavirus and prostate cancer: A meta-analysis.Oncology letters · 2017Article
- The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients.Radiology and oncology · 2016Article
- Are biomarkers evaluated in biopsy specimens predictive of prostate cancer aggressiveness?Journal of cancer research and clinical oncology · 2016Article
- Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.Frontiers in oncology · 2015Article
- Early Human Papilloma Virus (HPV) Oncogenic Influences in Breast Cancer.Breast cancer : basic and clinical research · 2015Article
- Identification of Human Papilloma Viruses in Atheromatous Coronary Artery Disease.Frontiers in cardiovascular medicine · 2015Article
- Infections and inflammation in prostate cancer.American journal of clinical and experimental urology · 2013Article
- Lack of evidence of HPV etiology of prostate cancer following radical surgery and higher frequency of the Arg/Pro genotype in Turkish men with prostate cancer.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infection on survival in 150 primary PCa patients. One hundred twelve (74.67%) patients had positive expression of HPV E7 protein, which was evaluated in tumour tissue by immunohistochemistry. DNA analysis on a subset of cases confirmed HPV infection and revealed the presence of genotype 16. In Kaplan-Meier analysis, HPV-positive cancer patients showed worse overall survival (OS) (median 4.59 years) compared to HPV-negative (median 8.24 years, P = 0.0381). In multivariate analysis age (P < 0.001), Gleason score (P < 0.001), nuclear grading (P = 0.002), and HPV status (P = 0.034) were independent prognostic factors for OS. In our cohort, we observed high prevalence of HPV nuclear E7 oncoprotein and an association between HPV infection and PCa survival. In the debate about the oncogenic activity of HPV in PCa, our results further confirm the need for additional studies to clarify the possible role of HPV in prostate carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.