ArticleNucleic acids research2014
Genetic robustness and functional evolution of gene duplicates.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy.Nature communications · 2025Article
- Methods, applications, and computational challenges in bait capture enrichment.Cell reports methods · 2025Review
- Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System.International journal of molecular sciences · 2024Article
- Competition and evolutionary selection among core regulatory motifs in gene expression control.Nature communications · 2023Article
- A Simple Evolutionary Model of Genetic Robustness After Gene Duplication.Journal of molecular evolution · 2022Article
- Retention of duplicated genes in evolution.Trends in genetics : TIG · 2022Review
- The Role of Ancestral Duplicated Genes in Adaptation to Growth on Lactate, a Non-Fermentable Carbon Source for the YeastInternational journal of molecular sciences · 2021Article
- The Relationship between the Misfolding Avoidance Hypothesis and Protein Evolutionary Rates in the Light of Empirical Evidence.Genome biology and evolution · 2021Article
- Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases ofFrontiers in microbiology · 2021Article
- Transcriptional adaptation ineLife · 2020Article
- Duplication history and molecular evolution of the rbcS multigene family in angiosperms.Journal of experimental botany · 2019Article
- Paralog buffering contributes to the variable essentiality of genes in cancer cell lines.PLoS genetics · 2019Article
- Paralog dependency indirectly affects the robustness of human cells.Molecular systems biology · 2019Article
- Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila.Genome biology and evolution · 2019Article
- The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interaction pattern.PLoS computational biology · 2019Article
- The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns.Scientific reports · 2019Article
- Article
- The mammalian skeletal muscle DHPR has larger CaCell calcium · 2017Article
- Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation.PloS one · 2017Article
- The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa.PLoS genetics · 2016Article
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2 authors.
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Abstract
Gene duplications are a major source of evolutionary innovations. Understanding the functional divergence of duplicates and their role in genetic robustness is an important challenge in biology. Previously, analyses of genetic robustness were primarily focused on duplicates essentiality and epistasis in several laboratory conditions. In this study, we use several quantitative data sets to understand compensatory interactions between Saccharomyces cerevisiae duplicates that are likely to be relevant in natural biological populations. We find that, owing to their high functional load, close duplicates are unlikely to provide substantial backup in the context of large natural populations. Interestingly, as duplicates diverge from each other, their overall functional load is reduced. At intermediate divergence distances the quantitative decrease in fitness due to removal of one duplicate becomes smaller. At these distances, yeast duplicates display more balanced functional loads and their transcriptional control becomes significantly more complex. As yeast duplicates diverge beyond 70% sequence identity, their ability to compensate for each other becomes similar to that of random pairs of singletons.
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