ArticleScience (New York, N.Y.)2013
The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria.
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
108 citing papers in PubMed, 217 citations in OpenAlex.
- High-resolution, high-throughput detection of hidden antibiotic resistance with the dilution-and-delay (DnD) susceptibility assay.Nature communications · 2026Article
- Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria.Science advances · 2026Article
- Single-cell heterogeneity underpins antagonistic antibiotic interactions.Molecular systems biology · 2026Article
- Probing Antibiotic Inhibition in Small Bacterial Populations With Combinatorial Droplet Microfluidics.Small science · 2026Article
- Heterogeneity in responses to ribosome-targeting antibiotics mediated by bacterial RNA repair.Nature communications · 2025Article
- A mismatch between slow protein synthesis and fast environmental fluctuations determines tradeoffs in bacterial proteome allocation strategies.bioRxiv : the preprint server for biology · 2025Article
- Deciphering and steering population-level response under spatial drug heterogeneity on microhabitat structures.bioRxiv : the preprint server for biology · 2025Article
- Article
- Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria.Nature communications · 2025Article
- Habitat fragmentation enhances microbial collective defence.Journal of the Royal Society, Interface · 2025Article
- Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications.Journal of the Royal Society, Interface · 2025Article
- Linking spatial drug heterogeneity to microbial growth dynamics in theory and experiment.bioRxiv : the preprint server for biology · 2024Article
- The master regulator OxyR orchestrates bacterial oxidative stress response genes in space and time.Cell systems · 2024Article
- Bacterial aggregation triggered by low-level antibiotic-mediated lysis.NPJ biofilms and microbiomes · 2024Article
- Fluid flow drives phenotypic heterogeneity in bacterial growth and adhesion on surfaces.Nature communications · 2024Article
- Synergy of lytic phage pB23 and meropenem combination against carbapenem-resistantAntimicrobial agents and chemotherapy · 2024Article
- Dynamical model of antibiotic responses linking expression of resistance genes to metabolism explains emergence of heterogeneity during drug exposures.Physical biology · 2024Article
- Quantifying Dynamic Phenotypic Heterogeneity in Resistant Escherichia coli under Translation-Inhibiting Antibiotics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Gene expression tradeoffs determine bacterial survival and adaptation to antibiotic stress.bioRxiv : the preprint server for biology · 2024Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
To predict the emergence of antibiotic resistance, quantitative relations must be established between the fitness of drug-resistant organisms and the molecular mechanisms conferring resistance. These relations are often unknown and may depend on the state of bacterial growth. To bridge this gap, we have investigated Escherichia coli strains expressing resistance to translation-inhibiting antibiotics. We show that resistance expression and drug inhibition are linked in a positive feedback loop arising from an innate, global effect of drug-inhibited growth on gene expression. A quantitative model of bacterial growth based on this innate feedback accurately predicts the rich phenomena observed: a plateau-shaped fitness landscape, with an abrupt drop in the growth rates of cultures at a threshold drug concentration, and the coexistence of growing and nongrowing populations, that is, growth bistability, below the threshold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.