ArticleScience (New York, N.Y.)2013
Nonenzymatic template-directed RNA synthesis inside model protocells.
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
170 citing papers in PubMed.
- Article
- MgJournal of the American Chemical Society · 2026Article
- Prebiotic β-Strand Peptides May Be a Plausible Solution to the Protocell Permeability Problem.Journal of molecular evolution · 2026Review
- Increasing the Compositional Heterogeneity of Single-Chain Amphiphile Membranes Supported by Coacervate Cores Alters Stability and Properties of the Hybrid Protocells.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Proteinoid Computing on Olivine Substrates.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Organocatalyzed bottom-up formation of protocells.Nature communications · 2026Article
- Complex and Messy Prebiotic Chemistry: Obstacles and Opportunities for an RNA World.Life (Basel, Switzerland) · 2026Review
- Brave new RNA world(s): from prebiotic chemistry to gene regulation and RNA technology.Frontiers in genetics · 2026Review
- The secret life of RNA and lipids.RNA biology · 2025Review
- Protopeptide backbone affects assembly in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Protocellular energy transduction, information and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Autocatalytic Reaction between HCN and Cysteamine Produces Hydrophobic, Catalytic, Liquid Compartments.Journal of the American Chemical Society · 2025Article
- Evo-Inspired Engineering of Radical Phenotypes and Emergent Traits.Integrative and comparative biology · 2025Review
- Polymerization and replication of primordial RNA induced by clay-water interface dynamics.Communications chemistry · 2025Article
- Nonenzymatic Primer Extension Experiments in the Presence of Coacervates.Current protocols · 2025Article
- On an RNA-Membrane Protogenome.Life (Basel, Switzerland) · 2025Article
- Chemiosmotic ATP synthesis by minimal protocells.Cell reports. Physical science · 2025Article
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Growing functional artificial cytoskeletons in the viscoelastic confinement of DNA synthetic cells.Nature chemical engineering · 2025Article
- Hybrid Protocells Based on Coacervate-Templated Fatty Acid Vesicles Combine Improved Membrane Stability with Functional Interior Protocytoplasm.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Efforts to recreate a prebiotically plausible protocell, in which RNA replication occurs within a fatty acid vesicle, have been stalled by the destabilizing effect of Mg(2+) on fatty acid membranes. Here we report that the presence of citrate protects fatty acid membranes from the disruptive effects of high Mg(2+) ion concentrations while allowing RNA copying to proceed, while also protecting single-stranded RNA from Mg(2+)-catalyzed degradation. This combination of properties has allowed us to demonstrate the chemical copying of RNA templates inside fatty acid vesicles, which in turn allows for an increase in copying efficiency by bathing the vesicles in a continuously refreshed solution of activated nucleotides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.