ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
Anterior-posterior regionalized gene expression in the Ciona notochord.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Fine-Tuned Expression of Evolutionarily Conserved Signaling Molecules in theInternational journal of molecular sciences · 2024Article
- Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network.Integrative and comparative biology · 2024Review
- The ion channel Anoctamin 10/TMEM16K coordinates organ morphogenesis across scales in the urochordate notochord.PLoS biology · 2024Article
- Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum.BMC ecology and evolution · 2023Article
- Single-cell analysis of cell fate bifurcation in the chordate Ciona.BMC biology · 2021Article
- Brachyury controlsDevelopment (Cambridge, England) · 2021Article
- Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships.PLoS genetics · 2021Article
- The notochord gene regulatory network in chordate evolution: Conservation and divergence from Ciona to vertebrates.Current topics in developmental biology · 2020Review
- Multiple inputs into a posterior-specific regulatory network in the Ciona notochord.Developmental biology · 2019Article
- Dynamic interplay of cell fate, polarity and force generation in ascidian embryos.Current opinion in genetics & development · 2018Review
- A temperature-adjusted developmental timer for precise embryonic staging.Biology open · 2018Article
- Functional and evolutionary insights from theDevelopment (Cambridge, England) · 2017Article
- Article
- Stochasticity and stereotypy in the Ciona notochord.Developmental biology · 2015Article
- A one-dimensional model of PCP signaling: polarized cell behavior in the notochord of the ascidian Ciona.Developmental biology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn the simple ascidian chordate Ciona, the signaling pathways and gene regulatory networks giving rise to initial notochord induction are largely understood and the mechanisms of notochord morphogenesis are being systematically elucidated. The notochord has generally been thought of as a non-compartmentalized or regionalized organ that is not finely patterned at the level of gene expression. Quantitative imaging methods have recently shown, however, that notochord cell size, shape, and behavior vary consistently along the anterior-posterior (AP) axis.
resultsHere we screen candidate genes by whole mount in situ hybridization for potential AP asymmetry. We identify 4 genes that show non-uniform expression in the notochord. Ezrin/radixin/moesin (ERM) is expressed more strongly in the secondary notochord lineage than the primary. CTGF is expressed stochastically in a subset of notochord cells. A novel calmodulin-like gene (BCamL) is expressed more strongly at both the anterior and posterior tips of the notochord. A TGF-β ortholog is expressed in a gradient from posterior to anterior. The asymmetries in ERM, BCamL, and TGF-β expression are evident even before the notochord cells have intercalated into a single-file column.
conclusionsWe conclude that the Ciona notochord is not a homogeneous tissue but instead shows distinct patterns of regionalized gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.