ArticleIn vitro cellular & developmental biology. Animal2014
Identification and distribution of rRNH1, a gene upregulated after spinal cord primary neuron injury.
Article in In vitro cellular & developmental biology. Animal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Chromatolysis: Do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA?Developmental neurobiology · 2018Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous study identified and characterized one differentially expressed gene, Rattus norvegicus ribonuclease/angiogenin inhibitor 1 (rRNH1). Transcriptional activity of lots of genes involves in spinal cord injury (SCI) and regeneration, but the mechanisms remain unknown. In the present study, we analyzed the sequences of rRNH1 and examined the expression pattern of rRNH1 in different adult rat tissues. We found the sequences of rRNH1 show high homology to Homo sapiens ribonuclease/angiogenin inhibitor 1; it encoded a protein of 461 amino acid residues and contained 13 leucine-rich repeat motifs. Using real-time quantitative PCR (q-PCR), rRNH1 mRNA was widely expressed in adult rat tissues, especially in the central nervous system. Moreover, rRNH1 protein was found to be upregulated after SCI. Although the precise function of rRNH1 is unknown, its unique expression pattern and upregulation after SCI suggest that rRNH1 might be involved in the succeeding injury and/or regeneration processes of injured spinal cord. All these data make rRNH1 a new interesting start to study the mechanisms of SCI and neuron regeneration.
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