ReviewCellular and molecular life sciences : CMLS2014
Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Comprehensive pan-cancer analysis of NLRs family as prognostic and immunity markers based on multi-omics data.Discover oncology · 2025Article
- Aberrant DNA methylation as a key modulator of cell death pathways: insights into cancer progression and other diseases.Functional & integrative genomics · 2025Review
- AIM2 and Psoriasis.Frontiers in immunology · 2023Review
- ASC Regulates Subcutaneous Adipose Tissue Lipogenesis and Lipolysis via p53/AMPKα Axis.International journal of molecular sciences · 2022Article
- Article
- Epigenetic Mechanisms of Inflammasome Regulation.International journal of molecular sciences · 2020Review
- Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- The Inflammasome Adaptor ASC Intrinsically Limits CD4Frontiers in immunology · 2019Article
- Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy.Frontiers in immunology · 2018Review
- Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy.Frontiers in immunology · 2018Review
- Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice.Mediators of inflammation · 2018Article
- Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer.Scientific reports · 2017Article
- Assembly and regulation of ASC specks.Cellular and molecular life sciences : CMLS · 2017Review
- Novel role of ASC as a regulator of metastatic phenotype.Cancer medicine · 2016Article
- AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Circadian disruption and breast cancer: an epigenetic link?Oncotarget · 2015Review
- Article
- Pathways of tumor development and progression in drug-induced nonmelanoma skin cancer: a new hope or the next great confusion?Wiener medizinische Wochenschrift (1946) · 2014Article
- Pyoderma gangrenosum: pathogenetic oriented treatment approaches.Wiener medizinische Wochenschrift (1946) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cloning studies have revealed that the apoptosis-associated speck-like protein possessing a caspase-recruiting domain (ASC) and the target of methylation-induced silencing-1 (TMS) are identical proteins. ASC/TMS1 is a bipartite adaptor protein containing the N-terminal pyrin domain and the C-terminal caspase-recruitment domain. There is abundant literature on ASC/TMS1, mostly under the name TMS1, in the epigenetic regulation of apoptosis and carcinogenesis, whereas the abbreviation ASC has been adopted from studies on the assembly of inflammasomes and stimulation of inflammation. There is substantial literature emphasizing that there are common aspects in the regulation of apoptosis and inflammation, which may be related to the function of ASC/TMS1. The region of the transcription start site of ASC/TMS1 gene contains a 600-bp-long CpG island that is highly methylated and the transcription of ASC/TMS1 is repressed in several cancers. However, it is not known whether the ASC/TMS1-dependent epigenetic regulation controls the inflammasome functions and moreover whether this regulation has any role in the inflammation-mediated carcinogenesis or in the pathogenesis of age-related degenerative diseases. We will examine the mechanisms involved in the epigenetic regulation of ASC/TMS1 as well as their significance in the coordination of apoptosis and inflammasome functions. We will also review the role of aberrant methylation of ASC/TMS1 promoter in the function of inflammasomes, a major host defense system, in cellular housekeeping and carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.