ArticleEuropean archives of psychiatry and clinical neuroscience2014
Gene expression in superior temporal cortex of schizophrenia patients.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What genes are differentially expressed in individuals with schizophrenia? A systematic review.Molecular psychiatry · 2022Pooled it
- Roles of autophagy in brain homeostasis and disease.Nature neuroscience · 2026Review
- Genetic and neural mechanisms shared by schizophrenia and depression.Molecular psychiatry · 2025Article
- Analysis of single-cell transcriptome data from a mouse model implicates protein synthesis dysfunction in schizophrenia.Genes & genomics · 2024Article
- Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population.Physiological genomics · 2018Article
- Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders.Molecular and cellular neurosciences · 2016Review
- [Neurobiology of schizophrenia: new findings from the structure to the molecules].Der Nervenarzt · 2015Review
- The neuropathology of schizophrenia: new insights from postmortem studies.European archives of psychiatry and clinical neuroscience · 2014Article
- Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
15 authors.
Funding
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Abstract
We investigated gene expression pattern obtained from microarray data of 10 schizophrenia patients and 10 control subjects. Brain tissue samples were obtained postmortem; thus, the different ages of the patients at death also allowed a study of the dynamic behavior of the expression patterns over a time frame of many years. We used statistical tests and dimensionality reduction methods to characterize the subset of genes differentially expressed in the two groups. A set of 10 genes were significantly downregulated, and a larger set of 40 genes were upregulated in the schizophrenia patients. Interestingly, the set of upregulated genes includes a large number of genes associated with gene transcription (zinc finger proteins and histone methylation) and apoptosis. We furthermore identified genes with a significant trend correlating with age in the control (MLL3) or the schizophrenia group (SOX5, CTRL). Assessments of correlations of other genes with the disorder (RRM1) or with the duration of medication could not be resolved, because all patients were medicated. This hypothesis-free approach uncovered a series of genes differentially expressed in schizophrenia that belong to a number of distinct cell functions, such as apoptosis, transcriptional regulation, cell motility, energy metabolism and hypoxia.
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