ArticleMagma (New York, N.Y.)2014
A preliminary study on the effects of acute ethanol ingestion on default mode network and temporal fractal properties of the brain.
Article in Magma (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Complexity in disguise: a systematic review of fractal analysis in psychiatric neuroimaging.European radiology · 2026Pooled it
- Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry · 2024Pooled it
- Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- Recreational alcohol use induces changes in the concentrations of choline-containing compounds and total creatine in the brain: a (1)H MRS study of healthy subjects.Magma (New York, N.Y.) · 2015Trial
- Ketamine-induced analgesia and dissociation show distinct behavioral and neural correlates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor.PloS one · 2026Article
- Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.Human brain mapping · 2025Article
- Models of psychedelic drug action: modulation of cortical-subcortical circuits.Brain : a journal of neurology · 2022Article
- Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine.The journal of headache and pain · 2020Article
- Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers.Alcoholism, clinical and experimental research · 2020Article
- Analysis of brain subnetworks within the context of their whole-brain networks.Human brain mapping · 2019Article
- Refined measure of functional connectomes for improved identifiability and prediction.Human brain mapping · 2019Article
- Global Effects of Focal Brain Tumors on Functional Complexity and Network Robustness: A Prospective Cohort Study.Neurosurgery · 2019Article
- Capturing Dynamic Connectivity from Resting State fMRI using Time-Varying Graphical Lasso.IEEE transactions on bio-medical engineering · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers.Molecular psychiatry · 2017Article
- Temporal fractal analysis of the rs-BOLD signal identifies brain abnormalities in autism spectrum disorder.PloS one · 2017Article
- Fractal Analysis of Brain Blood Oxygenation Level Dependent (BOLD) Signals from Children with Mild Traumatic Brain Injury (mTBI).PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectTo study the effect of acute alcohol intoxication on the functional connectivity of the default mode network (DMN) and temporal fractal properties of the healthy adult brain. MATERIALS AND
methodsEleven healthy male volunteers were asked to drink 0.59 g/kg of ethanol. Resting state blood oxygen level dependent (rsBOLD) MRI scans were obtained before consumption, 60 min post-consumption and 90 min post-consumption. Before each rsBOLD scan, pointed-resolved spectroscopy (PRESS) (1)H-MRS (magnetic resonance spectroscopy) scans were acquired to measure ethanol levels in the right basal ganglia.
resultsSignificant changes in DMN connectivity were found following alcohol consumption (p < 0.01). Both increased and decreased regional connectivity were found after 60 min, whereas mostly decreased connectivity was found after 90 min. The fractal behaviour of the rsBOLD signal, which is believed to help reveal complexity of small-scale neuronal circuitry, became more ordered after both 60 and 90 min of alcohol consumption (p < 0.01).
conclusionThe DMN has been linked to personal identity and social behavior. As such, our preliminary findings may provide insight into the neuro-functional underpinnings of the cognitive and behavioral changes observed during acute alcohol intoxication. The reduced fractal dimension implies a change in function of small-scale neural networks towards less complex signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.