Evidence map›Paper›PMID 24287161›Full record

ArticleActa biomaterialia2014

Mussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery.

J Jiang, J Xie, B Ma, D E Bartlett, A Xu, C-H Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 119 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Mussel-inspired biomaterials: From chemistry to clinic.Bioengineering & translational medicine · 2022
    Review
  7. Review
  8. On-Demand Drug Delivery Systems Using Nanofibers.Nanomaterials (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Micro and nanoscale technologies in oral drug delivery.Advanced drug delivery reviews · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

J JiangMarshall Institute for Interdisciplinary Research and Center for Diagnostic Nanosystems, Marshall University, Huntington, WV 25755, USA.
J XieMarshall Institute for Interdisciplinary Research and Center for Diagnostic Nanosystems, Marshall University, Huntington, WV 25755, USA. Electronic address: xiej@marshall.edu.
B MaMarshall Institute for Interdisciplinary Research and Center for Diagnostic Nanosystems, Marshall University, Huntington, WV 25755, USA.
D E BartlettMarshall Institute for Interdisciplinary Research and Center for Diagnostic Nanosystems, Marshall University, Huntington, WV 25755, USA.
A XuKey Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Sciences, Chinese Academy of Sciences, Hefei 230031, China.
C-H WangDepartment of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576 , Singapore.
Marshall University · USChinese Academy of Sciences · CNNational University of Singapore · SG

Funding

Combination of Nanofiber Scaffolds with Gradations in Fiber Organization and MineR15AR063901 · NIAMS · MARSHALL UNIVERSITY · PI SHULER, FRANKLIN D · 2013 to 2013
$293k
NIAMS NIH HHS 1R15AR063901-01NIAMS NIH HHS R15 AR063901
6 · The paper itself

Abstract

pH-responsive drug delivery systems could mediate drug releasing rate by changing the pH values at specific times as per the pathophysiological need of the disease. This paper demonstrates that a mussel-inspired protein polydopamine coating can tune the loading and releasing rate of charged molecules from electrospun poly(ε-caprolactone) (PCL) nanofibers in solutions with different pH values. In vitro release profiles show that the positive charged molecules release significantly faster in acidic than those in neutral and basic environments within the same incubation time. The results of fluorescein diacetate staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays show the viability of cancer cells after treatment with doxorubicin-released media at different pH values qualitatively and quantitatively, indicating that the media containing doxorubicin that were released in solutions at low pH values could kill a significantly higher number of cells than those released in solutions at high pH values. Together, the pH-responsive drug delivery systems based on polydopamine-coated PCL nanofibers could have potential application in the oral delivery of anticancer drugs for treating gastric cancer and in vaginal delivery of anti-viral drugs or anti-inflammatory drugs, which could raise their efficacy, deliver them to the specific target and minimize their toxic side effects.

Indexed as

AnimalsBivalviaCell Line, TumorCell SurvivalDoxorubicinDrug Delivery SystemsHumansHydrogen-Ion ConcentrationIndolesKineticsNanofibersNanotechnologyPolyestersPolymersProteinsRhodaminesDoxorubicinIndolespolycaprolactonepolydopaminePolyestersPolymersProteinsrhodamine 6GRhodaminesDrug deliveryElectrospun fiberspH sensitivePolydopamine coatingPoly(ε-caprolactone)

Identifiers

PMID24287161
PMCPMC3946753
OpenAlexW2153997464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.