ArticleDevelopmental cell2013
Loss of dE2F compromises mitochondrial function.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Conserved DNA architect couples chloroplast development to cell cycle in developing cotyledons.Nature plants · 2026Article
- A novel role for the E2F transcription factor and the ER stress sensor IRE1 in cytoplasmic DNA accumulation.Genetics · 2025Article
- Development of a rapamycin-inducible protein-knockdown system in the unicellular red alga Cyanidioschyzon merolae.Plant physiology · 2024Article
- Deregulated transcription factors in cancer cell metabolisms and reprogramming.Seminars in cancer biology · 2022Review
- Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.Cell reports · 2022Article
- Regulation and coordination of the different DNA damage responses inFrontiers in cell and developmental biology · 2022Review
- Article
- ILF2 cooperates with E2F1 to maintain mitochondrial homeostasis and promote small cell lung cancer progression.Cancer biology & medicine · 2019Article
- Review
- Transcriptional responses to DNA damage.DNA repair · 2019Review
- The broken cycle: E2F dysfunction in cancer.Nature reviews. Cancer · 2019Review
- E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression.Developmental cell · 2017Article
- HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy.EMBO molecular medicine · 2017Article
- Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.PloS one · 2017Article
- RNA sequencing of chorionic villi from recurrent pregnancy loss patients reveals impaired function of basic nuclear and cellular machinery.Scientific reports · 2016Article
- RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.The Journal of clinical investigation · 2016Article
- RB1: a prototype tumor suppressor and an enigma.Genes & development · 2016Review
- Article
- Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities.Cell reports · 2016Article
- E2F function in muscle growth is necessary and sufficient for viability in Drosophila.Nature communications · 2016Article
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7 authors at 4 institutions in 4 countries.
Funding
Abstract
E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, this is not due to an inability to induce the apoptotic transcriptional program, because we show that this program is induced; rather, this is due to a mitochondrial dysfunction of dDP mutants. We attribute this defect to E2F/DP-dependent control of expression of mitochondria-associated genes. Genetic attenuation of several of these E2F/DP targets mimics the dDP mutant mitochondrial phenotype and protects against irradiation-induced apoptosis. Significantly, the role of E2F/DP in the regulation of mitochondrial function is conserved between flies and humans. Thus, our results uncover a role of E2F/DP in the regulation of mitochondrial function and demonstrate that this aspect of E2F regulation is critical for the normal induction of apoptosis in response to irradiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.