ArticleThe open orthopaedics journal2013
In vitro elution characteristics of gentamicin and vancomycin from synthetic bone graft substitutes.
Article in The open orthopaedics journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- Efficacy comparison of antibiotic bone cement-coated implants and external fixations for treating infected bone defects.International orthopaedics · 2023Article
- Analysis of risk factors for serous exudation of biodegradable material calcium sulfate in the treatment of fracture-related infections.Frontiers in bioengineering and biotechnology · 2023Article
- Magnesium Modified β-Tricalcium Phosphate Induces Cell Osteogenic Differentiation In Vitro and Bone Regeneration In Vivo.International journal of molecular sciences · 2022Article
- Recent advances in the local antibiotics delivery systems for management of osteomyelitis.Drug delivery · 2021Review
- Silver ion doped hydroxyapatite-coated titanium pins prevent bacterial colonization.Joint diseases and related surgery · 2021Article
- Release of Antibiotics Out of a Moldable Collagen-β-Tricalciumphosphate-Composite Compared to Two Calcium Phosphate Granules.Materials (Basel, Switzerland) · 2019Article
- One-stage surgery for adult chronic osteomyelitis: concomitant use of antibiotic-loaded calcium sulphate and bone marrow aspirate.International orthopaedics · 2019Article
- Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections.Journal of bone and joint infection · 2017Review
- Biosafety of the Novel Vancomycin-loaded Bone-like Hydroxyapatite/Poly-amino Acid Bony Scaffold.Chinese medical journal · 2016Article
- Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study.Surgical infections · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectsBeta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb(®) and Cerasorb M(®) was tested.
methodsAntibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA).
resultsInitially both materials showed a high release of the loaded antibiotics, with Cerasorb M(®) showing lower release levels for gentamicin and vancomycin than Cerasorb(®). Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M(®) granules stayed above the detection threshold during the experimental time.
conclusionsCerasorb(®) and Cersorb M(®) may represent a new treatment option in osteomyelitis and infectious bone disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.