ArticleEvidence-based complementary and alternative medicine : eCAM2013
Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Preparation and characterization ofFrontiers in pharmacology · 2024Article
- The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn-A Review.Pharmaceutics · 2023Review
- B1 repetitive sequence methylation enhances wound healing of second-degree burns in rats.Biomedical reports · 2022Article
- Antioxidant and Cytoprotective Potential of the Essential OilAntioxidants (Basel, Switzerland) · 2021Article
- The Comparison of Clinical and Histopathological Effects of Topical Psyllium (World journal of plastic surgery · 2021Article
- Burn Care in the Greek and Roman Antiquity.Medicina (Kaunas, Lithuania) · 2020Review
- Wound Healing Activity of the Essential Oil ofMolecules (Basel, Switzerland) · 2020Article
- The Wound Healing Potential ofEvidence-based complementary and alternative medicine : eCAM · 2019Review
- Preventive Effect of Different Wild Pistachio Oils on Oxidative Stress Markers, Liver Enzymes, and Histopathological Findings in a Metabolic Syndrome Model.Galen medical journal · 2019Article
- Effects of Baneh (Iranian journal of pharmaceutical research : IJPR · 2019Article
- Effect ofWorld journal of plastic surgery · 2018Article
- The effect of Saqez (Pistacia atlantica) ointment on the treatment of nipple fissure and nipple pain in breastfeeding women.Electronic physician · 2017Article
- The effect ofIranian journal of basic medical sciences · 2016Article
- The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat.World journal of plastic surgery · 2015Article
- Article
- Evaluation of the protective and therapeutic effects ofAvicenna journal of phytomedicineArticle
- The effect of Saqez (Avicenna journal of phytomedicineArticle
- Effect of Malva sylvestris cream on burn injury and wounds in rats.Avicenna journal of phytomedicineArticle
- Cytotoxicity and antiangiogenic effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk oleoresin methanol extracts.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives. The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing. Methods. Thirty-two Wistar rats were divided into four groups and treated by vehicle, 5%, 10%, and 20% concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3, and G4, resp.). The efficacy of treatment was assessed based on reduction of burn wound size and histological and molecular characteristics. Results. α -Pinene (46.57%) was the main content of essential oil of resin. There were no statistically significant differences between groups according to wound size analysis. The mean histological wound healing scores were not statistically different. Capillary counts of G2 and G3 were significantly higher than those of the G1 (P = 0.042 and 0.032, resp.). NO concentration in wound fluids on the 5th day of study was not significantly different between groups (P = 0.468). But bFGF concentration in G2 and G3 and PDGF concentration in G3 were significantly higher in comparison to G1 (P = 0.043, 0.017, and 0.019, resp.). Conclusion. Our results revealed that Pistacia atlantica resin extract has a concentration-dependent effect on the healing of burn wounds after 14 days of treatment by increasing the concentration of bFGF and PDGF and also through improving the angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.