ReviewClinical & developmental immunology2013
Altered immune regulation in type 1 diabetes.
Review in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Immune dysregulation in type 2 diabetes mellitus: Implications for tuberculosis, COVID-19, and HIV/AIDS.Infectious medicine · 2025Review
- GαJournal of the Endocrine Society · 2024Article
- COVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group.Rheumatology international · 2024Article
- Islet transplantation-immunological challenges and current perspectives.World journal of transplantation · 2023Review
- Activation of T cell checkpoint pathways during β-cell antigen presentation by engineered dendritic cells promotes protection from type 1 diabetes.Immunology · 2022Article
- Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes.International journal of molecular sciences · 2022Review
- Family Support towards Resilience in Adolescents with Type I Diabetes: A Preliminary Study in Indonesia.Asian/Pacific Island nursing journal · 2019Article
- Autoimmunity and intestinal colonization by Candida albicans in patients with type 1 diabetes at the time of the diagnosis.Korean journal of pediatrics · 2018Article
- Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes.PloS one · 2017Article
- Metabolic crosstalk between host and pathogen: sensing, adapting and competing.Nature reviews. Microbiology · 2016Review
- Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies.Journal of diabetes research · 2015Review
- Multi-ethnic minority nurses' knowledge and practice of genetics and genomics.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research in genetics and immunology was going on separate strands for a long time. Type 1 diabetes mellitus might not be characterized with a single pathogenetic factor. It develops when a susceptible individual is exposed to potential triggers in a given sequence and timeframe that eventually disarranges the fine-tuned immune mechanisms that keep autoimmunity under control in health. Genomewide association studies have helped to understand the congenital susceptibility, and hand-in-hand with the immunological research novel paths of immune dysregulation were described in central tolerance, apoptotic pathways, or peripheral tolerance mediated by regulatory T-cells. Epigenetic factors are contributing to the immune dysregulation. The interplay between genetic susceptibility and potential triggers is likely to play a role at a very early age and gradually results in the loss of balanced autotolerance and subsequently in the development of the clinical disease. Genetic susceptibility, the impaired elimination of apoptotic β -cell remnants, altered immune regulatory functions, and environmental factors such as viral infections determine the outcome. Autoreactivity might exist under physiologic conditions and when the integrity of the complex regulatory process is damaged the disease might develop. We summarized the immune regulatory mechanisms that might have a crucial role in disease pathology and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.