ArticleDisease markers2013
Association between -308 G/A TNF-α polymorphism and appendicular skeletal muscle mass index as a marker of sarcopenia in normal weight obese syndrome.
Article in Disease markers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Association of normal weight obesity phenotype with inflammatory markers: A systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial.Journal of translational medicine · 2017Trial
- Diabetes in adolescents without obesity in India: An underrecognized phenotype.World journal of clinical pediatrics · 2025Article
- Normal Weight Obesity Overview and Update: A narrative review.Current obesity reports · 2025Review
- Ultra-Processed Food Intake and Increased Risk of Obesity: A Narrative Review.Foods (Basel, Switzerland) · 2024Review
- Clinical Classification of Obesity and Implications for Metabolic Dysfunction-Associated Fatty Liver Disease and Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Lean nonalcoholic fatty liver disease and sarcopenia.Frontiers in endocrinology · 2023Review
- The Risk of Sarcopenia among Adults with Normal-Weight Obesity in a Nutritional Management Setting.Nutrients · 2022Article
- Normal weight obesity and unaddressed cardiometabolic health risk-a narrative review.International journal of obesity (2005) · 2021Review
- Fasting: How to Guide.Nutrients · 2021Article
- Impaired Cardiorespiratory Fitness and Muscle Strength in Children with Normal-Weight Obesity.International journal of environmental research and public health · 2020Article
- Mediterranean Personalized Diet Combined with Physical Activity Therapy for the Prevention of Cardiovascular Diseases in Italian Women.Nutrients · 2020Observational
- From obesity through gut microbiota to cardiovascular diseases: a dangerous journey.International journal of obesity supplements · 2020Review
- TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.Molecular biology reports · 2020Article
- Obesity subtypes, related biomarkers & heterogeneity.The Indian journal of medical research · 2020Review
- Article
- Health impact of the Anthropocene: the complex relationship between gut microbiota, epigenetics, and human health, using obesity as an example.Global health, epidemiology and genomics · 2020Review
- Role of Personalized Nutrition in Chronic-Degenerative Diseases.Nutrients · 2019Review
- Prevention and Treatment of Sarcopenic Obesity in Women.Nutrients · 2019Review
- Why primary obesity is a disease?Journal of translational medicine · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimNormal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A -308 TNF-α polymorphism and prevalence of sarcopenia in NWO.
methodsWe enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A -308 TNF-α polymorphism.
resultsWe found a positive association between sarcopenic obesity and -308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P < 0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G.
conclusionOur study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome.
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