ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Processing of hedonic and chemosensory features of taste in medial prefrontal and insular networks.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed.
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- In praise of the hyperbola.Journal of the experimental analysis of behavior · 2026Review
- Neural coding in gustatory cortex reflects consumption decisions: evidence from conditioned taste aversion.Frontiers in systems neuroscience · 2026Article
- Adolescent nutritional influences on the brain: implications for eating behaviors.Neuropharmacology · 2025Review
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.bioRxiv : the preprint server for biology · 2025Article
- Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43Neurobiology of disease · 2025Article
- Neural Processing of Taste-Related Signals in the Mediodorsal Thalamus of Mice.bioRxiv : the preprint server for biology · 2025Article
- Gustatory cortex neurons perform reliability-dependent integration of multisensory flavor inputs.Current biology : CB · 2025Article
- Cortical coding of gustatory and thermal signals in active licking mice.The Journal of physiology · 2025Article
- Survey of temporal coding of sensory information.Frontiers in computational neuroscience · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.PloS one · 2025Article
- Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations.Biomedicines · 2024Article
- Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice.bioRxiv : the preprint server for biology · 2024Article
- Neuronal Activity in the Gustatory Cortex during Economic Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.PLoS computational biology · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.bioRxiv : the preprint server for biology · 2024Article
- Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex.Current biology : CB · 2024Article
- Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
9 more citing papers are in PubMed but not listed here.
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Abstract
Most of the research on cortical processing of taste has focused on either the primary gustatory cortex (GC) or the orbitofrontal cortex (OFC). However, these are not the only areas involved in taste processing. Gustatory information can also reach another frontal region, the medial prefrontal cortex (mPFC), via direct projections from GC. mPFC has been studied extensively in relation to its role in controlling goal-directed action and reward-guided behaviors, yet very little is known about its involvement in taste coding. The experiments presented here address this important point and test whether neurons in mPFC can significantly process the physiochemical and hedonic dimensions of taste. Spiking responses to intraorally delivered tastants were recorded from rats implanted with bundles of electrodes in mPFC and GC. Analysis of single-neuron and ensemble activity revealed similarities and differences between the two areas. Neurons in mPFC can encode the chemosensory identity of gustatory stimuli. However, responses in mPFC are sparser, more narrowly tuned, and have a later onset than in GC. Although taste quality is more robustly represented in GC, taste palatability is coded equally well in the two areas. Additional analysis of responses in neurons processing the hedonic value of taste revealed differences between the two areas in temporal dynamics and sensitivities to palatability. These results add mPFC to the network of areas involved in processing gustatory stimuli and demonstrate significant differences in taste-coding between GC and mPFC.
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