ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Motoneuron intrinsic properties, but not their receptive fields, recover in chronic spinal injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Muscle Spasms after Spinal Cord Injury Stem from Changes in Motoneuron Excitability and Synaptic Inhibition, Not Synaptic Excitation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks.Molecular neurobiology · 2021Review
- Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury.Journal of neuroscience research · 2020Article
- Vibration attenuates spasm-like activity in humans with spinal cord injury.The Journal of physiology · 2020Article
- Changes in Activity of Spinal Postural Networks at Different Time Points After Spinalization.Frontiers in cellular neuroscience · 2019Article
- Afferent input and sensory function after human spinal cord injury.Journal of neurophysiology · 2018Review
- Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure.Journal of neurotrauma · 2017Review
- Reflex wind-up in early chronic spinal injury: plasticity of motor outputs.Journal of neurophysiology · 2017Article
- An ovine model of spinal cord injury.The journal of spinal cord medicine · 2017Article
- Activity-dependent redistribution of Kv2.1 ion channels on rat spinal motoneurons.Physiological reports · 2016Article
- Effects of acute spinalization on neurons of postural networks.Scientific reports · 2016Article
- Trunk robot rehabilitation training with active stepping reorganizes and enriches trunk motor cortex representations in spinal transected rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Motor unit firing rates during spasms in thenar muscles of spinal cord injured subjects.Frontiers in human neuroscience · 2014Article
- Gain control mechanisms in spinal motoneurons.Frontiers in neural circuits · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Proper movement execution relies on precise input processing by spinal motoneurons (MNs). Spinal MNs are activated by limb joint rotations. Typically, their movement-related receptive fields (MRRFs) are sharply focused and joint-specific. After acute spinal transection MRRFs become wide, but their manifestation is not apparent, as intrinsic excitability, primarily resulting from the loss of persistent inward currents (PICs), dramatically decreases. PICs undergo a remarkable recovery with time after injury. Here we investigate whether MRRFs undergo a recovery that parallels that of the PIC. Using the chronic spinal cat in acute terminal decerebrate preparations, we found that MRRFs remain expanded 1 month after spinal transaction, whereas PICs recovered to >80% of their preinjury amplitudes. These recovered PICs substantially amplified the expanded inputs underlying the MRRFs. As a result, we show that single joint rotations lead to the activation of muscles across the entire limb. These results provide a potential mechanism for the propagation of spasms throughout the limb.
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