ArticleThe Plant cell2013
RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- EdU-Based Quantitative Analysis of Cell Proliferation in Arabidopsis Root Meristems.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Thermosensory reconfiguration of the auxin transcriptional pathway to drive root cell growth.Nature communications · 2026Article
- smoppix: unified nonparametric analysis of single-molecule spatial omics data using probabilistic indices.Genome biology · 2026Article
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- Identification of a Specific Role of Dihydrozeatin in the Regulation of the Cell Differentiation Activity inPlants (Basel, Switzerland) · 2025Article
- RETINOBLASTOMA-RELATED Has Both Canonical and Noncanonical Regulatory Functions During Thermo-Morphogenic Responses in Arabidopsis Seedlings.Plant, cell & environment · 2025Article
- Crosstalk among plant hormone regulates the root development.Plant signaling & behavior · 2024Review
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- Telomeres: an organized string linking plants and mammals.Biology direct · 2024Review
- BIG coordinates auxin and SHORT ROOT to promote asymmetric stem cell divisions in Arabidopsis roots.Plant cell reports · 2024Article
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- A Journey to the Core of the Plant Cell Cycle.International journal of molecular sciences · 2022Review
- Involvement of cytokinins in STOP1-mediated resistance to proton toxicity.Stress biology · 2022Article
- Live Plant Cell Tracking: Fiji plugin to analyze cell proliferation dynamics and understand morphogenesis.Plant physiology · 2022Article
- Histidine kinase inhibitors impair shoot regeneration inFrontiers in plant science · 2022Article
- Auxin Interactions with Other Hormones in Plant Development.Cold Spring Harbor perspectives in biology · 2021Review
- Hormonal Regulation and Crosstalk of Auxin/Cytokinin Signaling Pathways in Potatoes In Vitro and in Relation to Vegetation or Tuberization Stages.International journal of molecular sciences · 2021Article
- Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?Cancers · 2021Review
- Protein Levels of Several Arabidopsis Auxin Response Factors Are Regulated by Multiple Factors and ABA PromotesInternational journal of molecular sciences · 2020Article
- Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintenance of mitotic cell clusters such as meristematic cells depends on their capacity to maintain the balance between cell division and cell differentiation necessary to control organ growth. In the Arabidopsis thaliana root meristem, the antagonistic interaction of two hormones, auxin and cytokinin, regulates this balance by positioning the transition zone, where mitotically active cells lose their capacity to divide and initiate their differentiation programs. In animals, a major regulator of both cell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA. Here, we show that similarly to its homolog in animal systems, the plant RETINOBLASTOMA-RELATED (RBR) protein regulates the differentiation of meristematic cells at the transition zone by allowing mRNA accumulation of AUXIN RESPONSE FACTOR19 (ARF19), a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ARABIDOPSIS RESPONSE REGULATOR12 are required to activate the transcription of ARF19, which is involved in promoting cell differentiation and thus root growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.