ArticleThe Plant cell2013
Gene coexpression analysis reveals complex metabolism of the monoterpene alcohol linalool in Arabidopsis flowers.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 126 citations in OpenAlex.
- Terpenoids fromPlants (Basel, Switzerland) · 2026Review
- Neuroprotective and Neurotrophic Potential ofNutrients · 2025Article
- TPS genes expression pattern and terpenoids content in the leaves and flowers of Chimonanthus praecox and C. salicifolius.Scientific reports · 2025Article
- Discovery and characterisation of terpenoid biosynthesis enzymes from Daphniphyllum macropodum.BMC plant biology · 2025Article
- Phylogeny and Functional Differentiation of the Terpene Synthase Gene Family in Angiosperms with Emphasis onInternational journal of molecular sciences · 2025Article
- ACT2.6: Global Gene Coexpression Network inGenes · 2025Article
- Genome-wide identification and functional analysis of CYP450 genes in eggplant (Solanum melongena L.) with a focus on anthocyanin accumlation.BMC genomics · 2024Article
- Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages.BMC plant biology · 2023Article
- Formation of 8-hydroxylinalool in tea plantFood chemistry. Molecular sciences · 2023Article
- Hydroxylases involved in terpenoid biosynthesis: a review.Bioresources and bioprocessing · 2023Review
- Plant terpene specialized metabolism: complex networks or simple linear pathways?The Plant journal : for cell and molecular biology · 2023Review
- Biogenesis of flavor-related linalool is diverged and genetically conserved in tree peony (Horticulture research · 2023Article
- Insights into the Cytochrome P450 Monooxygenase Superfamily inInternational journal of molecular sciences · 2022Article
- Metabolomic Profiling in Combination with Data Association Analysis Provide Insights about Potential Metabolic Regulation Networks among Non-Volatile and Volatile Metabolites inPlants (Basel, Switzerland) · 2022Article
- Linalool Activates Oxidative and Calcium Burst and CAM3-ACA8 Participates in Calcium Recovery in Arabidopsis Leaves.International journal of molecular sciences · 2022Article
- Differential gene expression associated with a floral scent polymorphism in the evening primrose Oenothera harringtonii (Onagraceae).BMC genomics · 2022Article
- Terpene synthases in cucumber (Cucumis sativus) and their contribution to herbivore-induced volatile terpenoid emission.The New phytologist · 2022Article
- Functional conservation of Anopheline linalool receptors through 100 million years of evolution.Chemical senses · 2022Article
- Insights Into the MYB-Related Transcription Factors Involved in Regulating Floral Aroma Synthesis in Sweet Osmanthus.Frontiers in plant science · 2022Article
- Synthesis of flavour-related linalool is regulated by PpbHLH1 and associated with changes in DNA methylation during peach fruit ripening.Plant biotechnology journal · 2021Article
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytochrome P450 family encompasses the largest family of enzymes in plant metabolism, and the functions of many of its members in Arabidopsis thaliana are still unknown. Gene coexpression analysis pointed to two P450s that were coexpressed with two monoterpene synthases in flowers and were thus predicted to be involved in monoterpenoid metabolism. We show that all four selected genes, the two terpene synthases (TPS10 and TPS14) and the two cytochrome P450s (CYP71B31 and CYP76C3), are simultaneously expressed at anthesis, mainly in upper anther filaments and in petals. Upon transient expression in Nicotiana benthamiana, the TPS enzymes colocalize in vesicular structures associated with the plastid surface, whereas the P450 proteins were detected in the endoplasmic reticulum. Whether they were expressed in Saccharomyces cerevisiae or in N. benthamiana, the TPS enzymes formed two different enantiomers of linalool: (-)-(R)-linalool for TPS10 and (+)-(S)-linalool for TPS14. Both P450 enzymes metabolize the two linalool enantiomers to form different but overlapping sets of hydroxylated or epoxidized products. These oxygenated products are not emitted into the floral headspace, but accumulate in floral tissues as further converted or conjugated metabolites. This work reveals complex linalool metabolism in Arabidopsis flowers, the ecological role of which remains to be determined.
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