Evidence map›Paper›PMID 24285476›Full record

ArticleJournal of labelled compounds & radiopharmaceuticals2013

Synthesis of [1,3, NH2-(15)N3] (5'S)-8,5'-cyclo-2'-deoxyguanosine.

Chanchal K Malik, Rajat S Das, Ashis K Basu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of labelled compounds & radiopharmaceuticals, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chanchal K MalikDepartment of Chemistry, University of Connecticut, Storrs, CT, 06269, USA.
Rajat S Das
Ashis K Basu
University of Connecticut · US

Funding

Ring-Opened and Tandem DNA DamagesR01ES013324 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI BASU, ASHIS K · 2006 to 2010
$1.5M
NIEHS NIH HHS ES013324NIEHS NIH HHS R01 ES013324
6 · The paper itself

Abstract

To facilitate NMR studies and low-level detection in biological samples by mass spectrometry, [1,3, NH2-(15)N3] (5'S)-8,5'-cyclo-2'-deoxyguanosine was synthesized from imidazole-4,5-dicarboxylic acid in 21 steps. The three (15)N isotopes were introduced during the chemo-enzymatic preparation of [1,3, NH2-(15)N3]-2'-deoxyguanosine using an established procedure. The (15)N-labeled 2'-deoxyguanosine was converted to a 5'-phenylthio derivative, which allowed the 8-5' covalent bond formation via photochemical homolytic cleavage of the C-SPh bond. SeO2 oxidation of C-5' followed by sodium borohydride reduction and deprotection gave the desired product in good yield. The isotopic purity of the [1,3, NH2-(15)N3] (5'S)-8,5'-cyclo-2'-deoxyguanosine was in excess of 99.94 atom% based on liquid chromatography-mass spectrometry measurements.

Indexed as

DeoxyguanosineIsotope LabelingNitrogen Isotopes8,5'-cyclo-2'-deoxyguanosineDeoxyguanosineNitrogen Isotopes15N-S-cdGcyclo-dGtandem DNA lesionγ-radiation damage

Identifiers

PMID24285476
PMCPMC5382719
OpenAlexW1512215793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.