ArticleJAMA psychiatry2014
Parsing dimensional vs diagnostic category-related patterns of reward circuitry function in behaviorally and emotionally dysregulated youth in the Longitudinal Assessment of Manic Symptoms study.
Article in JAMA psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Dysregulated connectivity configuration of functional network model in first-episode, treatment-naive adolescents with major depressive disorder.BMC psychiatry · 2026Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- A network approach to the investigation of childhood irritability: probing frustration using social stimuli.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Executive functioning moderates neural mechanisms of irritability during reward processing in youth.Psychiatry research. Neuroimaging · 2022Article
- Phenoscreening: a developmental approach to research domain criteria-motivated sampling.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Repetitive Transcranial Magnetic Stimulation Improves Amygdale Functional Connectivity in Major Depressive Disorder.Frontiers in psychiatry · 2020Article
- Baseline and follow-up activity and functional connectivity in reward neural circuitries in offspring at risk for bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder.PloS one · 2019Article
- Neural responses to monetary incentives in bipolar disorder.NeuroImage. Clinical · 2019Article
- Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Temptations of friends: adolescents' neural and behavioral responses to best friends predict risky behavior.Social cognitive and affective neuroscience · 2018Article
- Reward-related neural activity and structure predict future substance use in dysregulated youth.Psychological medicine · 2017Article
- Irritability in Youths: A Translational Model.The American journal of psychiatry · 2017Review
- Irritability in Children and Adolescents.Annual review of clinical psychology · 2017Review
- Longitudinal relationships among activity in attention redirection neural circuitry and symptom severity in youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Article
- Executive function in children born preterm: Risk factors and implications for outcome.Seminars in perinatology · 2016Review
- Preliminary investigation of the relationships between sleep duration, reward circuitry function, and mood dysregulation in youth offspring of parents with bipolar disorder.Journal of affective disorders · 2016Article
- Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth.Molecular psychiatry · 2016Article
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Authors and funding
28 authors at 10 institutions in 2 countries.
Funding
Abstract
importancePediatric disorders characterized by behavioral and emotional dysregulation pose diagnostic and treatment challenges because of high comorbidity, suggesting that they may be better conceptualized dimensionally rather than categorically. Identifying neuroimaging measures associated with behavioral and emotional dysregulation in youth may inform understanding of underlying dimensional vs disorder-specific pathophysiologic features.
objectiveTo identify, in a large cohort of behaviorally and emotionally dysregulated youth, neuroimaging measures that (1) are associated with behavioral and emotional dysregulation pathologic dimensions (behavioral and emotional dysregulation measured with the Parent General Behavior Inventory 10-Item Mania Scale [PGBI-10M], mania, depression, and anxiety) or (2) differentiate diagnostic categories (bipolar spectrum disorders, attention-deficit/hyperactivity disorder, anxiety, and disruptive behavior disorders). DESIGN, SETTING, AND
participantsA multisite neuroimaging study was conducted from February 1, 2011, to April 15, 2012, at 3 academic medical centers: University Hospitals Case Medical Center, Cincinnati Children's Hospital Medical Center, and University of Pittsburgh Medical Center. Participants included a referred sample of behaviorally and emotionally dysregulated youth from the Longitudinal Assessment of Manic Symptoms (LAMS) study (n = 85) and healthy youth (n = 20). MAIN OUTCOMES AND MEASURES: Region-of-interest analyses examined relationships among prefrontal-ventral striatal reward circuitry during a reward paradigm (win, loss, and control conditions), symptom dimensions, and diagnostic categories.
resultsRegardless of diagnosis, higher PGBI-10M scores were associated with greater left middle prefrontal cortical activity (r = 0.28) and anxiety with greater right dorsal anterior cingulate cortical (r = 0.27) activity to win. The 20 highest (t = 2.75) and 20 lowest (t = 2.42) PGBI-10M-scoring youth showed significantly greater left middle prefrontal cortical activity to win compared with 20 healthy youth. Disruptive behavior disorders were associated with lower left ventrolateral prefrontal cortex activity to win (t = 2.68) (all P < .05, corrected). CONCLUSIONS AND RELEVANCE: Greater PGBI-10M-related left middle prefrontal cortical activity and anxiety-related right dorsal anterior cingulate cortical activity to win may reflect heightened reward sensitivity and greater attention to reward in behaviorally and emotionally dysregulated youth regardless of diagnosis. Reduced left ventrolateral prefrontal cortex activity to win may reflect reward insensitivity in youth with disruptive behavior disorders. Despite a distinct reward-related neurophysiologic feature in disruptive behavior disorders, findings generally support a dimensional approach to studying neural mechanisms in behaviorally and emotionally dysregulated youth.
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