Evidence map›Paper›PMID 24285020›Full record

SynthesisAnnals of oncology : official journal of the European Society for Medical Oncology2014

Factors influencing adherence to cancer treatment in older adults with cancer: a systematic review.

M T E Puts, H A Tu, A Tourangeau, D Howell, M Fitch, E Springall, S M H Alibhai

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of oncology : official journal of the European Society for Medical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04165460 (Effect of Two Cognitive-Behavioral Interventions on Psychosocial Factors and Quality of Life of Cervical Cancer Patients With Locally-advanced and Advanced Disease), which is not on this map. Cited by 95 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04165460 naenrolling by invitationnot on this mapstarted 2020, after this paper: background citation

Effect of Two Cognitive-Behavioral Interventions on Psychosocial Factors and Quality of Life of Cervical Cancer Patients With Locally-advanced and Advanced Disease

TypeinterventionalSponsorNational Institute of CancerologíaRan2020 to 2025Enrolled92ConditionsCervical Cancer, Psychological Distress, Coping SkillsArmsPsychoeducation, Relaxation, Cognitive Restructuring, Solving Problems
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effectiveness of Internet-based interventions in managing chemotherapy-related symptoms in patients with cancer: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  4. Pooled it
  5. Factors affecting uptake and adherence to breast cancer chemoprevention: a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2016
    Pooled it
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  8. Food to Overcome Outcomes Disparities: A Randomized Controlled Trial of Food Insecurity Interventions to Improve Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
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  15. Suicide among patients with cancer: a retrospective study of medical treatment-related factors associated with suicide.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M T E PutsLawrence S. Bloomberg Faculty of Nursing. Electronic address: martine.puts@utoronto.ca.
H A TuLawrence S. Bloomberg Faculty of Nursing; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto.
A TourangeauLawrence S. Bloomberg Faculty of Nursing.
D HowellLawrence S. Bloomberg Faculty of Nursing; Princess Margaret Hospital, University Health Network, Toronto.
M FitchLawrence S. Bloomberg Faculty of Nursing; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto.
E SpringallGerstein Science Information Centre, University of Toronto Libraries, Toronto.
S M H AlibhaiToronto General Hospital, University Health Network, Toronto, Canada; Department of Medicine and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer is a disease that mostly affects older adults. Treatment adherence is crucial to obtain optimal outcomes such as cure or improvement in quality of life. Older adults have numerous comorbidites as well as cognitive and sensory impairments that may affect adherence. The aim of this systematic review was to examine factors that influence adherence to cancer treatment in older adults with cancer. PATIENTS AND

methodsSystematic review of the literature published between inception of the databases and February 2013. English, Dutch, French and German-language articles reporting cross-sectional or longitudinal, intervention or observational studies of cancer treatment adherence were included. Data sources included MEDLINE, EMBASE, PsychINFO, Cumulative Index to Nursing and Allied Health (CINAHL), Web of Science, ASSIA, Ageline, Allied and Complementary Medicine (AMED), SocAbstracts and the Cochrane Library. Two reviewers reviewed abstracts and abstracted data using standardized forms. Study quality was assessed using the Mixed Methods Appraisal Tool 2011.

resultsTwenty-two manuscripts were identified reporting on 18 unique studies. The quality of most studies was good. Most studies focused on women with breast cancer and adherence to adjuvant hormonal therapy. More than half of the studies used data from administrative or clinical databases or chart reviews. The adherence rate varied from 52% to 100%. Only one qualitative study asked older adults about reasons for non-adherence. Factors associated with non-adherence varied widely across studies.

conclusionNon-adherence was common across studies but little is known about the factors influencing non-adherence. More research is needed to investigate why older adults choose to adhere or not adhere to their treatment regimens taking into account their multimorbidity.

Indexed as

Medication AdherenceAgedAged, 80 and overAgingCost-Benefit AnalysisHumansNeoplasmsagedcancer treatmentgeriatric oncologynon-adherencesystematic review

Identifiers

PMID24285020
PMCPMC4433503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.