ArticleToxins2013
The expression of type-1 and type-2 nitric oxide synthase in selected tissues of the gastrointestinal tract during mixed mycotoxicosis.
Article in Toxins, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Mycoestrogen Exposure during Pregnancy: Impact of theEnvironmental health perspectives · 2025Article
- Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases.Frontiers in pharmacology · 2024Review
- Evaluation of ELISA and immunoaffinity fluorometric analytical tools of four mycotoxins in various food categories.AMB Express · 2023Article
- Article
- Article
- Mycotoxins and the Enteric Nervous System.Toxins · 2020Review
- Time-Dependent Changes in the Intestinal Microbiome of Gilts Exposed to Low Zearalenone Doses.Toxins · 2019Article
- Article
- Mycotoxin: Its Impact on Gut Health and Microbiota.Frontiers in cellular and infection microbiology · 2018Review
- Activity of Zearalenone in the Porcine Intestinal Tract.Molecules (Basel, Switzerland) · 2016Review
- The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs--A Review.Molecules (Basel, Switzerland) · 2015Review
- Article
- The effect of experimental fusarium mycotoxicosis on microbiota diversity in porcine ascending colon contents.Toxins · 2014Article
- Deoxynivalenol in the gastrointestinal tract of immature gilts under per os toxin application.Toxins · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to verify the hypothesis that intoxication with low doses of mycotoxins leads to changes in the mRNA expression levels of nitric oxide synthase-1 and nitric oxide synthase-2 genes in tissues of the gastrointestinal tract and the liver. The experiment involved four groups of immature gilts (with body weight of up to 25 kg) which were orally administered zearalenone in a daily dose of 40 μg/kg BW (group Z, n = 18), deoxynivalenol at 12 μg/kg BW (group D, n = 18), zearalenone and deoxynivalenol (group M, n = 18) or placebo (group C, n = 21) over a period of 42 days. The lowest mRNA expression levels of nitric oxide synthase-1 and nitric oxide synthase-2 genes were noted in the sixth week of the study, in particular in group M. Our results suggest that the presence of low mycotoxin doses in feed slows down the mRNA expression of both nitric oxide synthase isomers, which probably lowers the concentrations of nitric oxide, a common precursor of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.