ArticleThe Journal of antimicrobial chemotherapy2014
Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England.
Article in The Journal of antimicrobial chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 84 citations in OpenAlex.
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- Characterizing Methicillin-ResistantAnimals : an open access journal from MDPI · 2024Article
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- Notification of bacterial strains made available by the United Kingdom National Collection of Type Cultures in 2022.Access microbiology · 2024Article
- Methicillin-ResistantIranian journal of public health · 2023Review
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- Notification List of Bacterial Strains Made Available by the United Kingdom National Collection of Type Cultures in 2021.Microbiology resource announcements · 2022Article
- Rapid Detection of PBP2a in Staphylococci from Shortly Incubated Subcultures of Positive Blood Cultures by an Immunochromatographic Assay.Microbiology spectrum · 2021Article
- Prevalence and characterization ofJAC-antimicrobial resistance · 2021Article
- Clonal Diversity, Low-Level and Heterogeneous Oxacillin Resistance of Oxacillin Sensitive MRSA.Infection and drug resistance · 2021Article
- Genomic Analysis ofFrontiers in microbiology · 2021Article
- First report of methicillin-resistantNew microbes and new infections · 2021Article
- HumanMicroorganisms · 2020Review
- Phenotype and Genotype Characteristics ofMicrobial drug resistance (Larchmont, N.Y.) · 2020Article
- Marked Presence of Methicillin-ResistantAnimals : an open access journal from MDPI · 2020Article
- Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThere are limited data available on the epidemiology and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the human population that encode the recently described mecA homologue, mecC. To address this knowledge gap we undertook a prospective prevalence study in England to determine the prevalence of mecC among MRSA isolates. PATIENTS AND
methodsThree hundred and thirty-five sequential MRSA isolates from individual patients were collected from each of six clinical microbiology laboratories in England during 2011-12. These were tested by PCR or genome sequencing to differentiate those encoding mecA and mecC. mecC-positive isolates were further characterized by multilocus sequence typing, spa typing, antimicrobial susceptibility profile and detection of PBP2a using commercially available kits.
resultsNine out of the 2010 MRSA isolates tested were mecC positive, indicating a prevalence among MRSA in England of 0.45% (95% CI 0.24%-0.85%). The remainder were mecA positive. Eight out of these nine mecC MRSA isolates belonged to clonal complex 130, the other being sequence type 425. Resistance to non-β-lactam antibiotics was rare among these mecC MRSA isolates and all were phenotypically identified as MRSA using oxacillin and cefoxitin according to BSAC disc diffusion methodology. However, all nine mecC isolates gave a negative result using three different commercial PBP2a detection assays.
conclusionsmecC MRSA are currently rare among MRSA isolated from humans in England and this study provides an important baseline prevalence rate to monitor future changes, which may be important given the increasing prevalence of mecC MRSA reported in Denmark.
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