ArticleScientific reports2013
Slow-spinning low-sideband HR-MAS NMR spectroscopy: delicate analysis of biological samples.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use ofScientific reports · 2021Trial
- Live Metabolomics with NMR.Analytical chemistry · 2026Review
- Chemical Profiling and Quality Assessment of Food Products Employing Magnetic Resonance Technologies.Foods (Basel, Switzerland) · 2025Review
- High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region.International journal of molecular sciences · 2024Article
- HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.Metabolites · 2019Review
- Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats.Scientific reports · 2017Article
- On the use of ultracentrifugal devices for routine sample preparation in biomolecular magic-angle-spinning NMR.Journal of biomolecular NMR · 2017Article
- Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy.Analytical chemistry · 2016Article
- Proteomics, and metabolomics: magnetic resonance spectroscopy for the presurgical screening of thyroid nodules.Current genomics · 2014Article
- Pitfalls to be considered on the metabolomic analysis of biological samples by HR-MAS.Frontiers in chemistry · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-Resolution Magic-Angle Spinning (HR-MAS) NMR spectroscopy has become an extremely versatile analytical tool to study heterogeneous systems endowed with liquid-like dynamics. Spinning frequencies of several kHz are however required to obtain NMR spectra, devoid of spinning sidebands, with a resolution approaching that of purely isotropic liquid samples. An important limitation of the method is the large centrifugal forces that can damage the structure of the sample. In this communication, we show that optimizing the sample preparation, particularly avoiding air bubbles, and the geometry of the sample chamber of the HR-MAS rotor leads to high-quality low-sideband NMR spectra even at very moderate spinning frequencies, thus allowing the use of well-established solution-state NMR procedures for the characterization of small and highly dynamic molecules in the most fragile samples, such as live cells and intact tissues.
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