Evidence map›Paper›PMID 24284387›Full record

Trial reportJournal of human hypertension2014

The impact of aerobic exercise on blood pressure variability.

N Pagonas, F Dimeo, F Bauer, F Seibert, F Kiziler, W Zidek, T H Westhoff

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Walking for hypertension.The Cochrane database of systematic reviews · 2021
    Pooled it
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  12. Effects of Physical Exercise on Endothelial Function and DNA Methylation.International journal of environmental research and public health · 2019
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

N PagonasDepartment of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
F DimeoDepartment of Sports Medicine, Charité-Campus Benjamin Franklin, Berlin, Germany.
F BauerDepartment of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
F SeibertDepartment of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
F KizilerDepartment of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
W ZidekDepartment of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
T H WesthoffDepartment of Nephrology, Charité-Campus Benjamin Franklin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing evidence that blood pressure variability (BPV, variation of blood pressure over time) constitutes a strong and independent marker of cardiovascular risk. The all-cause mortality is >50% greater in subjects with a standard deviation of inter-visit blood pressure >5 mm Hg. Regular aerobic exercise reduces blood pressure and is recommended by current hypertension guidelines as a basic lifestyle modification. It remains elusive, however, whether aerobic exercise is able to reduce BPV as well. In total, 72 hypertensive subjects were randomly assigned to an 8-12-week treadmill exercise program (target lactate 2.0±0.5 mmol l(-1)) or sedentary control. Blood pressure was measured by 24 h-ambulatory blood pressure monitoring (ABP). Two aspects of BPV were assessed: the variability of ABP and the variability of blood pressure on exertion. The coefficient of variation (CV) was used as a statistical measure of BPV. The CV of systolic daytime ABP was defined as primary outcome. The exercise program significantly decreased systolic and diastolic daytime ABP by 6.2±10.2 mm Hg (P<0.01) and 3.0±6.3 mm Hg (P=0.04), respectively. Moreover, it reduced blood pressure on exertion and increased physical performance (P<0.05 each). Exercise had no impact, however, on the CV of daytime (10.2±2.7 vs. 9.8±2.6%, P=0.30) and night-time systolic (8.9±3.2 vs. 10.5±4.1%, P=0.10) and diastolic ABP (daytime 11.5±3.3 vs. 11.5±3.1%, night-time 12.0±4.3 vs. 13.8±5.2%; P>0.05 each). Regular aerobic exercise is a helpful adjunct to control blood pressure in hypertension, but it has no effect on 24 h- BPV, an independent predictor of cardiovascular risk.

Indexed as

Sedentary BehaviorAdultBlood PressureBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesExerciseExercise TestFemaleFollow-Up StudiesGermanyHumansHypertensionMaleMiddle AgedMultivariate AnalysisPatient Selection

Identifiers

PMID24284387
OpenAlexW2025205856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.