ArticleJournal of human hypertension2014
Deregulation of adipokines related to target organ damage on resistant hypertension.
Article in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Relationship between circulating leptin levels and arterial stiffness: a systematic review and meta-analysis of observational studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Pooled it
- Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review.Biomedicines · 2024Review
- Not Only Metabolic Complications of Childhood Obesity.Nutrients · 2024Review
- Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3-5.Adipocyte · 2020Article
- Estrogen-related mechanisms in sex differences of hypertension and target organ damage.Biology of sex differences · 2020Review
- Pro-inflammatory Cytokines and Resistant Hypertension: Potential for Novel Treatments?Current hypertension reports · 2019Review
- A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated with Resistant Hypertension, but Dependent on Obesity Parameters.Arquivos brasileiros de cardiologia · 2019Article
- Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease.Journal of vascular surgery · 2019Article
- Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Subjects.Arquivos brasileiros de cardiologia · 2018Article
- Continuous Positive Airway Pressure Reduces Night-Time Blood Pressure and Heart Rate in Patients With Obstructive Sleep Apnea and Resistant Hypertension: The RHOOSAS Randomized Controlled Trial.Frontiers in neurology · 2018Article
- Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists.Vascular health and risk management · 2017Review
- Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Association of serum leptin levels with central arterial stiffness in coronary artery disease patients.BMC cardiovascular disorders · 2016Article
- Role of MMP-2 and MMP-9 in resistance to drug therapy in patients with resistant hypertension.Arquivos brasileiros de cardiologia · 2015Article
- Positive correlation of serum adipocyte fatty acid binding protein levels with carotid-femoral pulse wave velocity in geriatric population.BMC geriatrics · 2015Article
- Adipokines: another link between obesity and hypertension.Journal of human hypertension · 2015Article
- Resistant or refractory hypertension: are they different?Current hypertension reports · 2014Review
- Adipokines: novel players in resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2014Review
- Resistant hypertension in diabetes mellitus.Current diabetes reports · 2014Review
- Association of hyperleptinemia with peripheral arterial disease in hypertensive patients.Tzu chi medical journalArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistant hypertension (RHTN) includes patients with controlled blood pressure (BP) (CRHTN) and uncontrolled BP (UCRHTN). In fact, RHTN patients are more likely to have target organ damage (TOD), and resistin, leptin and adiponectin may affect BP control in these subjects. We assessed the relationship between adipokines levels and arterial stiffness, left ventricular hypertrophy (LVH) and microalbuminuria (MA). This cross-sectional study included CRHTN (n=51) and UCRHTN (n=38) patients for evaluating body mass index, ambulatory blood pressure monitoring, plasma adiponectin, leptin and resistin concentrations, pulse wave velocity (PWV), MA and echocardiography. Leptin and resistin levels were higher in UCRHTN, whereas adiponectin levels were lower in this same subgroup. Similarly, arterial stiffness, LVH and MA were higher in UCRHTN subgroup. Adiponectin levels negatively correlated with PWV (r=-0.42, P<0.01), and MA (r=-0.48, P<0.01) only in UCRHTN. Leptin was positively correlated with PWV (r=0.37, P=0.02) in UCRHTN subgroup, whereas resistin was not correlated with TOD in both subgroups. Adiponectin is associated with arterial stiffness and renal injury in UCRHTN patients, whereas leptin is associated with arterial stiffness in the same subgroup. Taken together, our results showed that those adipokines may contribute to vascular and renal damage in UCRHTN patients.
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