ArticleJournal of virology2014
Genetic resistance to scrapie infection in experimentally challenged goats.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 80 citations in OpenAlex.
- Incomplete protection of the KVeterinary research · 2026Article
- Silent Propagation of Classical Scrapie Prions in Homozygous KEmerging infectious diseases · 2025Article
- Prion protein gene (PRNP) variation in German and Danish cervids.Veterinary research · 2024Article
- National Prevalence of Caprine Prion Protein Genetic Variability at Codons 146, 211, and 222 in Goat Herds in the United States.Veterinary sciences · 2023Article
- Article
- Polymorphisms of Codons 110, 146, 211 and 222 at the GoatAnimals : an open access journal from MDPI · 2021Article
- Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPGenetics, selection, evolution : GSE · 2021Article
- Genetic Variation in the Prion Protein Gene (Animals : an open access journal from MDPI · 2021Article
- Neuropathology of Animal Prion Diseases.Biomolecules · 2021Review
- Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases.Animals : an open access journal from MDPI · 2021Review
- From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics.Biomolecules · 2021Review
- Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States.PloS one · 2021Article
- Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.Scientific reports · 2020Article
- PRNP gene polymorphisms in main indigenous Turkish goat breeds.Tropical animal health and production · 2020Article
- Goats naturally devoid of PrPVeterinary research · 2020Article
- Classical Scrapie Did Not Re-occur in Goats After Cleaning and Disinfection of the Farm Premises.Frontiers in veterinary science · 2020Article
- Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods.Veterinary research · 2019Article
- Potential scrapie-associated polymorphisms of the prion protein gene (PRNP) in Korean native black goats.Scientific reports · 2019Article
- Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe.Veterinary research · 2019Article
- Two novel amino acid substitutions in highly conserved regions of prion protein (PrP) and a high frequency of a scrapie protective variant in native Ethiopian goats.BMC veterinary research · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In goats, several field studies have identified coding mutations of the gene encoding the prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a lower risk of developing classical scrapie. However, the data related to the levels of resistance to transmissible spongiform encephalopathies (TSEs) of these different PRNP gene mutations are still considered insufficient for developing large-scale genetic selection against scrapie in this species. In this study, we inoculated wild-type (WT) PRNP (I142R154R211Q222) goats and homozygous and/or heterozygous I/M142, R/H154, R/Q211, and Q/K222 goats with a goat natural scrapie isolate by either the oral or the intracerebral (i.c.) route. Our results indicate that the I/M142 PRNP polymorphism does not provide substantial resistance to scrapie infection following intracerebral or oral inoculation. They also demonstrate that H154, Q211, and K222 PRNP allele carriers are all resistant to scrapie infection following oral exposure. However, in comparison to WT animals, the H154 and Q211 allele carriers displayed only moderate increases in the incubation period following i.c. challenge. After i.c. challenge, heterozygous K222 and a small proportion of homozygous K222 goats also developed the disease, but with incubation periods that were 4 to 5 times longer than those in WT animals. These results support the contention that the K222 goat prion protein variant provides a strong but not absolutely protective effect against classical scrapie.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.