Evidence map›Paper›PMID 24283885›Full record

ReviewEpigenomics2013

Epigenetic effects of green tea polyphenols in cancer.

Susanne M Henning, Piwen Wang, Catherine L Carpenter, David Heber

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epigenomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Polyphenols as Potent Epigenetics Agents for Cancer.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Healthy Effects of Plant Polyphenols: Molecular Mechanisms.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Susanne M HenningCenter for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, 900 Veteran Avenue, Warren Hall 14-166, Los Angeles, CA 90095, USA.
Piwen Wang
Catherine L Carpenter
David Heber
University of California, Los Angeles · USCharles R. Drew University of Medicine and Science · US

Funding

Tea Polyphenols in Chemoprevention of Prostate CancerR01CA116242 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HENNING, SUSANNE MARGARETE · 2007 to 2011
$1.3M
Quercetin to enhance the bioavailability and activity of green tea polyphenolsR03CA171583 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HENNING, SUSANNE MARGARETE · 2013 to 2014
$152k
NCI NIH HHS R01 CA116242NCI NIH HHS R03 CA171583
6 · The paper itself

Abstract

Epigenetics describes heritable alterations of gene expression and chromatin organization without changes in DNA sequence. Both hypermethylation and hypomethylation of DNA can affect gene expression and the multistep process of carcinogenesis. Epigenetic changes are reversible and may be targeted by dietary interventions. Bioactive compounds from green tea (GT) such as (-)-epigallocatechin gallate have been shown to alter DNA methyltransferase activity in studies of esophageal, oral, skin, Tregs, lung, breast and prostate cancer cells, which may contribute to the chemopreventive effect of GT. Three out of four mouse model studies have confirmed the inhibitory effect of (-)-epigallocatechin gallate on DNA methylation. A human study demonstrated that decreased methylation of CDX2 and BMP-2 in gastric carcinoma was associated with higher GT consumption. It is the goal of this review to summarize our current knowledge of the potential of GT to alter epigenetic processes, which may be useful in chemoprevention.

Indexed as

Epigenesis, GeneticAnimalsBone Morphogenetic Protein 2CatechinCDX2 Transcription FactorDietDNA MethylationGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansNeoplasmsPolyphenolsTeaTrans-ActivatorsBone Morphogenetic Protein 2CatechinCDX2 Transcription Factorepigallocatechin gallateHomeodomain ProteinsPolyphenolsTeaTrans-Activators

Identifiers

PMID24283885
PMCPMC3970408
OpenAlexW2155995135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.