ReviewGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2014
Luteinizing hormone and human chorionic gonadotropin: distinguishing unique physiologic roles.
Review in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples.Hormones and behavior · 2020Pooled it
- Unveiling Endotypes in Systemic Lupus Erythematosus Through Multiomic Analysis: Insights Into Cardiovascular and Renal Complications.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Effects of Preovulatory hCG Administration on Follicular Dynamics, Reproductive Hemodynamics, Nitric Oxide, and VEGF Levels in Mares.Veterinary sciences · 2026Article
- Association of LH rising before luteal support and reproductive outcomes in artificial frozen embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Integrated hormonal, metabolic, and epigenetic regulation of corpus luteum function: insights into steroidogenesis, angiogenesis, and regression.Frontiers in endocrinology · 2026Review
- Review
- Lycopene in male infertility.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Molecular characterization of the murine Leydig cell lines TM3 and MLTC-1.Frontiers in endocrinology · 2025Article
- The Cardiometabolic Risk in Women with Polycystic Ovarian Syndrome (PCOS): From Pathophysiology to Diagnosis and Treatment.Medicina (Kaunas, Lithuania) · 2024Review
- Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations.Archives of toxicology · 2024Article
- Anogenital distance in a cohort of 169 infant boys with uni- or bilateral cryptorchidism including 18 boys with vanishing testes.Human reproduction (Oxford, England) · 2024Article
- The ovaries of transgender men indicate effects of high dose testosterone on the primordial and early growing follicle pool.Reproduction & fertility · 2023Article
- Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?International journal of environmental research and public health · 2023Review
- Serum LH level prior to progestin administration is significant on pregnancy and live birth in programmed frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2023Article
- Clinical aspects of histological and hormonal parameters in boys with cryptorchidism: Thesis for PhD degree.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Article
- Maternal Testosterone Concentrations in Third Trimester and Offspring Handgrip Strength at 5 Years: Odense Child Cohort.The Journal of clinical endocrinology and metabolism · 2022Article
- Low Perinatal Androgens Predict Recalled Childhood Gender Nonconformity in Men.Psychological science · 2022Article
- The GnRH Antagonist Degarelix Suppresses Gonadotropin Secretion and Pituitary Sensitivity in Midgestation Sheep Fetuses.Endocrinology · 2022Article
- A pregnancy hormone-cell death link promotes enhanced lupus-specific immunological effects.Frontiers in immunology · 2022Article
- Evidence that perinatal ovarian hormones promote women's sexual attraction to men.Psychoneuroendocrinology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are integral components of the hypothalamic-pituitary-gonadal axis, which controls sexual maturation and functionality. In the absence of signaling through their shared receptor, fetal sexual differentiation and post-natal development cannot proceed normally. Although they share a high degree of homology, the physiologic roles of these hormones are unique, governed by differences in expression pattern, biopotency and regulation. Whereas LH is a key regulator of gonadal steroidogenesis and ovulation, hCG is predominantly active in pregnancy and fetal development. Emerging evidence has revealed endogenous functions not previously ascribed to hCG, including participation in ovulation and fertilization, implantation, placentation and other activities in support of successful pregnancy. Spontaneous and induced mutations in LH, hCG and their mutual receptor have contributed substantially to our understanding of reproductive development and function. The lack of naturally occurring, functionally significant mutations in the β-subunit of hCG reinforce its putative role in establishment of pregnancy. Rescue of reproductive abnormalities resulting from aberrant gonadotropin signaling is possible in certain clinical contexts, depending on the nature of the underlying defect. By understanding the physiologic roles of LH and hCG in normal and pathologic states, we may better harness their diagnostic, prognostic and therapeutic potential.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.