ArticleDNA and cell biology2014
The occurrence of fetal microchimeric cells in endometrial tissues is a very common phenomenon in benign uterine disorders, and the lower prevalence of fetal microchimerism is associated with better uterine cancer prognoses.
Article in DNA and cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Male-origin microchimerism and risk of cancer: a systematic review and meta‑analysis.BMC cancer · 2025Pooled it
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association of cesarean section with breast cancer: A systematic review and meta-analysis.Molecular and clinical oncology · 2025Article
- Sex, male origin microchimerism, and mortality in a Danish cohort.European journal of epidemiology · 2025Article
- The duality of microchimerism and cancer in parous women: a review and evolutionary perspective.Seminars in immunopathology · 2025Review
- The Microchimerism Literature Atlas.Bioinformatics and biology insights · 2025Article
- A history of cesarean section and future maternal long-term risk for neoplasms: a population-based cohort study.Archives of gynecology and obstetrics · 2023Article
- Is chimerism associated with cancer across the tree of life?PloS one · 2023Article
- Novel insights into the link between fetal cell microchimerism and maternal cancers.Journal of cancer research and clinical oncology · 2016Review
- Fetal microchimerism and maternal health: a review and evolutionary analysis of cooperation and conflict beyond the womb.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Interbirth intervals: Intrafamilial, intragenomic and intrasomatic conflict.Evolution, medicine, and public health · 2014Article
- Positive effect of fetal cell microchimerism on tumor presentation and outcome in papillary thyroid cancer.Chimerism · 2014Article
- Does microchimerism mediate kin conflicts?Chimerism · 2014Article
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7 authors.
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Abstract
This is the first study carried out to describe the role of fetal microchimerism (FM) in the pathogenesis of uterine cancer. The prevalence and concentration of male fetal microchimeric cells (FMCs) were examined in endometrial tissues in relation to subtypes of uterine cancer, and the histological grade and stage of the tumor. FM occurrence was analyzed in relation to risk factors, including hypertension, obesity, type 2 diabetes, dyslipidemia, age at cancer diagnosis, and patient pregnancy history. The prevalence and concentration of FMCs were examined in endometrial tissues using real-time polymerase chain reaction, SRY and β-globin sequences as markers for male fetal FMCs and total DNA. The studied group involved 47 type 1 endometrial cancers, 28 type 2 endometrial cancers, and 41 benign uterine diseases. While the prevalence of FM was decreased only in type 1 endometrial cancer, compared with benign uterine disorders (38.3% vs.70.7%; odds ratio [OR]=0.257, 95% confidence interval [CI]: 0.105 to 0.628, p=0.003), FMC concentrations did not differ within examined groups. The lower FM prevalence was detected in low-grade (grade 1 and grade 2) endometrioid cancer (38.3% vs. 70.7%, OR=0.256, 95% CI: 0.105 to 0.627, p=0.003) and in FIGO 1 tumors (40.7% vs. 70.7%, OR=0.285, 95% CI: 0.120 to 0.675, p=0.004). No correlation between FM prevalence or FMC concentrations and risk factors was demonstrated. A lower prevalence of male FM seemed to be associated with better prognoses in uterine cancer based on tumor subtype, histological grade, and stage of the tumor.
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