ReviewInternational dental journal2013
The primary and mixed dentition, post-eruptive enamel maturation and dental caries: a review.
Review in International dental journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Comparative evaluation of BRIX3000 and Carisolv in chemomechanical caries removal in immature permanent first molars: a randomized controlled trial.BMC oral health · 2025Trial
- Association of Parental Oral Health Knowledge and Self-Efficacy with Early Childhood Caries and Oral Health Quality of Life in Texas Schoolchildren.International journal of environmental research and public health · 2025Trial
- Effect of Fluoride Varnish in Preventing Dental Caries of First Permanent Molars: A 24-Month Cluster Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Impact of the intermediary layer on sealant retention: a randomized 24-month clinical trial.Clinical oral investigations · 2017Trial
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- AI-based applications supporting informal caregivers in childhood caries prevention and management: protocol for a scoping review.BMJ open · 2026Article
- Pulpotomy in Primary Molars with Deep Caries Using Biodentine: A Case Series with 1-Year Follow-Up.Dentistry journal · 2026Article
- Micro-CT Assessment of Dentin Mineral Density and Furcation Morphology in Primary First and Second Molars.Dentistry journal · 2026Article
- Effect of Fluoride Varnishes Containing Casein Phosphopeptide-amorphous Calcium Phosphate on Primary Enamel Microhardness: AnInternational journal of clinical pediatric dentistry · 2026Article
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Uncovering the hidden costs of Molar Incisor Hypomineralization (MIH): the impact of later diagnosis on clinical outcomes and financial cost.Odontology · 2026Article
- Nonsurgical Endodontic Management of an Odontogenic Cutaneous Sinus Tract in a Child: A Case Report.Children (Basel, Switzerland) · 2026Article
- Microbial Composition of Carious Dentin and the Impact of Minimally Invasive Excavation Techniques: A Narrative Review.International journal of molecular sciences · 2026Review
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Cross-cultural adaptation of Caregiver oral health knowledge questionnaire and its association with oral health status among Vietnamese children and adolescents with Autism Spectrum Disorder.Journal of public health research · 2026Article
- Resin-Modified Calcium Silicate-Based Materials Versus Conventional Formulations in Primary Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Outcomes of Vital Pulp Therapy Procedures in Pediatric Dentistry.Journal of functional biomaterials · 2026Review
- Article
- Salivary pH within multifactorial caries risk assessment in children: observational clinical evidence using the Cariogram platform.Frontiers in oral health · 2026Article
- The Effect of Laser Surface Treatment on the Bond Strength of Adhesive Materials to Primary Teeth: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouth is in flux from the time the primary teeth begin to erupt, in the first year of life, through to the end of the 'mixed dentition' (i.e. the concurrent eruption of the permanent teeth and exfoliation of the primary teeth), at around 12 years of age. Primary teeth facilitate the development of the facial muscles and speech. They act as 'guides' for erupting permanent teeth. If lost prematurely, subsequent misalignment of permanent teeth can make them difficult to clean and possibly more caries-prone. During the mixed dentition phase, teeth are at relatively high risk of caries. Erupting teeth are difficult to clean and cleaning may be avoided because of tender gums and behavioural factors in children. Permanent enamel (and possibly primary enamel) undergoes post-eruptive maturation, accumulating fluoride, becoming harder, less porous and less caries-prone. Overall, primary teeth are more vulnerable to caries than permanent teeth. Widespread use of fluoride toothpaste has effected marked reductions in caries. Some evidence exists that fluoride delivered from toothpastes may be somewhat more effective in reducing caries in primary than in permanent teeth. However, caries remains a public health concern globally. New fluoride toothpaste formulations, optimised using in vivo fluoride delivery and efficacy studies, may improve the caries resistance of mineral deposited during post-eruptive maturation. Behaviour should not be ignored; new formulations will be more effective if used according to professionally endorsed recommendations based on sound science. Establishing good oral hygiene behaviour early in life can lead to lasting anti-caries benefits.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.