ArticleJournal of hematology & oncology2013
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia.
Article in Journal of hematology & oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs.Journal of cellular and molecular medicine · 2026Article
- Favorable response to second-line sirolimus regardless ofTherapeutic advances in hematology · 2026Article
- T-cell Large Granular Lymphocytic Leukemia with a STAT3 Mutation Successfully Treated with Cord Blood Transplantation.Internal medicine (Tokyo, Japan) · 2025Article
- Somatic mutations associate with clonal expansion of CD8Science advances · 2024Article
- The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders.Blood cancer journal · 2024Review
- A case report of T-LGL leukemia-associated pure red cell aplasia harboring STAT3, TNFAIP3, and KMT2D mutation.Translational cancer research · 2023Article
- Clinical characteristics and outcomes of 100 adult patients with pure red cell aplasia.Annals of hematology · 2022Article
- [Clinical characteristics of T-cell large granular lymphoblastic leukemia with STAT3 gene mutation].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021Article
- Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides.Molecular cancer therapeutics · 2021Review
- Acquired pure red cell aplasia and T cell large granular lymphocytic leukaemia in patients with autoimmune polyglandular syndrome type 1.BMC medical genomics · 2021Article
- Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations.Cancer medicine · 2020Article
- Identification of aHaematologica · 2020Article
- [Clinical and laboratory characteristics in patients with myeloid neoplasms complicated with clonal T large granular lymphocyte proliferation].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Article
- [Chinese expert consensus on the diagnosis and treatment of acquired pure red cell aplasia (2020)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Article
- Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia.Frontiers in oncology · 2020Review
- STAT3 Activation and Oncogenesis in Lymphoma.Cancers · 2019Review
- Review
- T-cell large granular lymphocytic (LGL) leukemia consists of CD4Journal of clinical and experimental hematopathology : JCEH · 2019Article
- Pathophysiologic Mechanisms And Management Of Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia.OncoTargets and therapy · 2019Article
- FrequentBlood advances · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder and can cooccur in the context of pure red cell aplasia (PRCA). The aim of the current study was to analyze the signal transducer and activator of transcription 3 (STAT3) mutation status and its clinical significance in T-LGLL. We found STAT3 mutations in 21.4% of patients with T-LGLL. High ß2-MG (ß2-microglobulin) levels (P = 0.005), neutropenia (P = 0.018) and PRCA (P = 0.001) all displayed a significant association with STAT3 mutations. In univariate analysis, treatment-free survival (TFS) was affected by STAT3 mutation status (P=0.008) and ß2-MG (P = 0.006). Our results demonstrate the remarkable correlation of STAT3 mutation with PRCA, neutropenia and ß2-MG.
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