ArticleNephro-urology monthly2013
Does living donor hyperoxia have an impact on kidney graft function after transplantation?
Article in Nephro-urology monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Effect of post-perfusion hyperoxemia on early graft function in renal transplant recipients: a retrospective observational cohort study.Irish journal of medical science · 2021Observational
- Time Dependent Pathway Activation of Signalling Cascades in Rat Organs after Short-Term Hyperoxia.International journal of molecular sciences · 2018Article
- Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells.Oxidative medicine and cellular longevity · 2017Article
- Hyperoxia-Induced Protein Alterations in Renal Rat Tissue: A Quantitative Proteomic Approach to Identify Hyperoxia-Induced Effects in Cellular Signaling Pathways.Disease markers · 2015Article
- Effects of pretreatment with single-dose or intermittent oxygen on Cisplatin-induced nephrotoxicity in rats.Nephro-urology monthly · 2014Article
- A commentary on: Does Living Donor Hyperoxia Have an Impact on Kidney Graft Function After Transplantation.Nephro-urology monthly · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImprovement in the outcome of organ transplantation is related to advances in patient selection criteria, organ preservation, operative techniques, perioperative care and efficacy of immunosuppressive agents.
objectivesWe aimed to evaluate the effects of higher levels of arterial PaO2 in donors on DGF (delayed graft function). PATIENTS AND
methodsForty patients over 18 years old with stage 4-5 chronic kidney disease (CKD) who received a kidney from living donors were enrolled. They were randomly grouped in to the case (n = 17) and control (n = 23) groups and were followed for 2 weeks after transplantation. Donors were exposed to 60% oxygen for at least 2 hours with a face-mask (venture mask) for 2 consecutive days before transplantation until arterial oxygen pressure increased in arterial blood gas to 200 mmHg. Neutrophil gelatinase associated lipocalin (NGAL), Interleuk-18 (IL-18), tumor necrosis factor- α (TNF-α) and transforming growth factor-β (TGF-β) could be good biomarkers for early diagnosis of kidney injury in renal transplant recipients; we assessed kidney function with these biomarkers.
resultsForty living kidney transplantations including 17 cases and 23 controls were performed; female gender was more prevalent in recipients (n = 16, 40%). The mean age of recipients was 36.1 ± 12.4 (18-67) years old. DGF was detected in 2 (5.95%) individuals, from whom one was in the case group and the other one in the control group. In the univariate analysis, there was no significant correlation between age and biomarkers in urine and serum unless for the second serum NGAL (P = 0.02, r = -0.06) and second urine IL 18 (P = 0.03, r = -0.5) which had a negative correlation, and first urine TNF α (P = 0.02, r = 0.7) which had a positive correlation.
conclusionsOxygen therapy in the case group had no significant impact on protection from DGF.
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