ArticlePeerJ2013
Predominant intragenic methylation is associated with gene expression characteristics in a bivalve mollusc.
Article in PeerJ, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 141 citations in OpenAlex.
- Article
- Prior exposure to hypoxia alters DNA methylation patterns in the eastern oyster.bioRxiv : the preprint server for biology · 2025Article
- Complementary genetic and epigenetic changes facilitate rapid adaptation to multiple global change stressors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Oysters in transition: hermaphrodite oysters display unique DNA methylation patterns in gill tissue.BMC genomics · 2025Article
- Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clamOpen biology · 2025Article
- Rapid Natural Killer Cell Gene Responses, Generated by TLR Ligand-Induced Trained Immunity, Provide Protection to Bacterial Infection inInternational journal of molecular sciences · 2025Article
- DNA Methylation Profiling in Genetically Selected Clarias magur (Hamilton, 1822) Provides Insights into the Epigenetic Regulation of Growth and Development.Marine biotechnology (New York, N.Y.) · 2024Article
- Unravelling epigenetic mechanisms in Cerastoderma edule genome: a comparison of healthy and neoplastic cockles.Molecular genetics and genomics : MGG · 2024Article
- DNA methylation correlates with transcriptional noise in response to elevated pCOEnvironmental epigenetics · 2024Article
- High temperature influences DNA methylation and transcriptional profiles in sea urchins (Strongylocentrotus intermedius).BMC genomics · 2023Article
- Epigenetic and Genetic Population Structure is Coupled in a Marine Invertebrate.Genome biology and evolution · 2023Article
- Comparative Methylome Analysis Reveals Epigenetic Signatures Associated with Growth and Shell Color in the Pacific Oyster, Crassostrea gigas.Marine biotechnology (New York, N.Y.) · 2022Article
- Differential DNA methylation in Pacific oyster reproductive tissue in response to ocean acidification.BMC genomics · 2022Article
- DNA Methylation Analyses Unveil a Regulatory Landscape in the Formation of Nacre Color in Pearl OysterFrontiers in genetics · 2022Article
- Article
- Population differences in Chinook salmon (Ecology and evolution · 2021Article
- Inference of DNA methylation patterns in molluscs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Genotoxic and epigenetic effects of diuron in the Pacific oyster: in vitro evidence of interaction between DNA damage and DNA methylation.Environmental science and pollution research international · 2021Article
- Article
- Environmentally Driven Color Variation in the Pearl OysterFrontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterization of DNA methylation patterns in the Pacific oyster, Crassostrea gigas, indicates that this epigenetic mechanism plays an important functional role in gene regulation and may be involved in the regulation of developmental processes and environmental responses. However, previous studies have been limited to in silico analyses or characterization of DNA methylation at the single gene level. Here, we have employed a genome-wide approach to gain insight into how DNA methylation supports the regulation of the genome in C. gigas. Using a combination of methylation enrichment and high-throughput bisulfite sequencing, we have been able to map methylation at over 2.5 million individual CpG loci. This is the first high-resolution methylome generated for a molluscan species. Results indicate that methylation varies spatially across the genome with a majority of the methylated sites mapping to intra genic regions. The bisulfite sequencing data was combined with RNA-seq data to examine genome-wide relationships between gene body methylation and gene expression, where it was shown that methylated genes are associated with high transcript abundance and low variation in expression between tissue types. The combined data suggest DNA methylation plays a complex role in regulating genome activity in bivalves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.