ArticlePloS one2013
Identification of glucose transporters in Aspergillus nidulans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- Advances in fungal sugar transporters: unlocking the potential of second-generation bioethanol production.Applied microbiology and biotechnology · 2025Review
- Structural and biochemical insights of xylose MFS and SWEET transporters in microbial cell factories: challenges to lignocellulosic hydrolysates fermentation.Frontiers in microbiology · 2024Review
- The Cerato-Platanin EPL2 fromMicroorganisms · 2023Article
- Discovery of ER-localized sugar transporters for cellulase production with lac1 being essential.Biotechnology for biofuels and bioproducts · 2022Article
- Article
- Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions inJournal of fungi (Basel, Switzerland) · 2021Article
- RCO-3 and COL-26 form an external-to-internal module that regulates the dual-affinity glucose transport system in Neurospora crassa.Biotechnology for biofuels · 2021Article
- Deuterium-labeled Raman tracking of glucose accumulation and protein metabolic dynamics in Aspergillus nidulans hyphal tips.Scientific reports · 2021Article
- Endocytosis of nutrient transporters in fungi: The ART of connecting signaling and trafficking.Computational and structural biotechnology journal · 2021Review
- Datamining and functional environmental genomics reassess the phylogenetics and functional diversity of fungal monosaccharide transporters.Applied microbiology and biotechnology · 2021Article
- Identification and Expression Analysis of Sugar Transporter Gene Family inInternational journal of genomics · 2020Article
- A pair of non-optimal codons are necessary for the correct biosynthesis of theRoyal Society open science · 2019Article
- Engineering of Pentose Transport inFrontiers in bioengineering and biotechnology · 2019Review
- Characterization of a novel sugar transporter involved in sugarcane bagasse degradation inBiotechnology for biofuels · 2018Article
- Article
- The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans.Scientific reports · 2017Article
- Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Genome biology · 2017Article
- Identification and characterization of the glucose dual-affinity transport system inBiotechnology for biofuels · 2017Article
- Identification of a Novel L-rhamnose Uptake Transporter in the Filamentous Fungus Aspergillus niger.PLoS genetics · 2016Article
- RNAseq reveals hydrophobins that are involved in the adaptation of Aspergillus nidulans to lignocellulose.Biotechnology for biofuels · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To characterize the mechanisms involved in glucose transport, in the filamentous fungus Aspergillus nidulans, we have identified four glucose transporter encoding genes hxtB-E. We evaluated the ability of hxtB-E to functionally complement the Saccharomyces cerevisiae EBY.VW4000 strain that is unable to grow on glucose, fructose, mannose or galactose as single carbon source. In S. cerevisiae HxtB-E were targeted to the plasma membrane. The expression of HxtB, HxtC and HxtE was able to restore growth on glucose, fructose, mannose or galactose, indicating that these transporters accept multiple sugars as a substrate through an energy dependent process. A tenfold excess of unlabeled maltose, galactose, fructose, and mannose were able to inhibit glucose uptake to different levels (50 to 80 %) in these s. cerevisiae complemented strains. Moreover, experiments with cyanide-m-chlorophenylhydrazone (CCCP), strongly suggest that hxtB, -C, and -E mediate glucose transport via active proton symport. The A. nidulans ΔhxtB, ΔhxtC or ΔhxtE null mutants showed ~2.5-fold reduction in the affinity for glucose, while ΔhxtB and -C also showed a 2-fold reduction in the capacity for glucose uptake. The ΔhxtD mutant had a 7.8-fold reduction in affinity, but a 3-fold increase in the capacity for glucose uptake. However, only the ΔhxtB mutant strain showed a detectable decreased rate of glucose consumption at low concentrations and an increased resistance to 2-deoxyglucose.
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