ArticlePloS one2013
Maternal age, parity and isolated birth defects: a population-based case-control study in Shenzhen, China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Congenital anomalies and maternal age: A systematic review and meta-analysis of observational studies.Acta obstetricia et gynecologica Scandinavica · 2022Pooled it
- Congenital anomalies in children exposed to antithyroid drugs in-utero: a meta-analysis of cohort studies.PloS one · 2015Pooled it
- Pooled it
- Magnitude, pattern, birth outcome, and determinants of congenital anomalies among newborns in Ethiopia.BMC pediatrics · 2025Article
- Maternal and perinatal characteristics associated with congenital anomalies: a case-control study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Season, household registry and isolated birth defects: a population-based case-control study in Danyang, China.International health · 2024Article
- Epidemiology of congenital malformations in Tunisian liveborns: a retrospective study.African health sciences · 2024Article
- Maternal pre-pregnancy overweight or obesity and risk of birth defects in offspring: Population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Epidemiology of congenital polydactyly and syndactyly in Hunan Province, China.BMC pregnancy and childbirth · 2024Article
- Update from a cohort study for birth defects in Hunan Province, China, 2010-2020.Scientific reports · 2023Article
- Analyzing the Trends and Causes of Birth Defects - Jinan City, Shandong Province, China, 2005-2022.China CDC weekly · 2023Article
- Epidemiology of birth defects in a national hospital-based birth defect surveillance spot in Southern Jiangsu, China, 2014-2018.Frontiers in medicine · 2023Article
- Could maternal stress be a causal factor for nonsyndromic cleft lip and/or palate: A retrospective study.National journal of maxillofacial surgery · 2022Article
- Beliefs on the causes of birth defects as perceived by mothers of children with birth defects in a tertiary care hospital in the Philippines.Journal of community genetics · 2022Article
- Epidemiology of Congenital Heart Disease in Jinan, China From 2005 to 2020: A Time Trend Analysis.Frontiers in cardiovascular medicine · 2022Article
- Risk factors for transposition of the great arteries in Saudi population.Saudi medical journal · 2020Article
- Epidemiology, prenatal diagnosis, and neonatal outcomes of congenital heart defects in eastern China: a hospital-based multicenter study.BMC pediatrics · 2020Article
- Birth Defects Data From Population-Based Birth Defects Surveillance System in a District of Southern Jiangsu, China, 2014-2018.Frontiers in public health · 2020Article
- Pregnancy and Neonatal Outcomes Following Prenatal Exposure to Dolutegravir.Journal of acquired immune deficiency syndromes (1999) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe etiology of birth defects has been widely studied but is not yet fully clarified, previously published data had suggested that maternal age or parity maybe involved, but without consistent conclusions.
methodsA population-based, case-control study was nested in a cohort of perinatal infants born from 2010 to 2012 in Baoan District, Shenzhen. Four categories of isolated birth defects were defined as cases: congenital heart defects (CHD, n = 693), polydactyly (n = 352), cleft lip with or without palate (CL/P, n = 159) and equinovarus (n = 119). Controls were non-malformed infants (n = 11,307) randomly selected from the same area and period. Odds ratios (ORs) and the 95% confidence intervals (CIs) were computed by multivariable unconditional logistic regression analysis.
resultsYoung maternal age (<25 years old) was associated with a reduced risk of CHD (adjusted OR = 0.73, 95% CI 0.59-0.90), while with an elevated risk of polydactyly (adjusted OR = 1.42, 95% CI 1.09-1.84). Increased risk of CL/P-affected pregnancy was observed in mothers older than 35 years old (adjusted OR = 2.12, 95% CI 1.26-3.57). Compared to primipara, those having their second, and third or more delivery were less likely to have infants with equinovarus, with significant adjusted ORs of 0.59 (0.40-0.89) and 0.42 (0.19-0.93), respectively.
conclusionMaternal age was significantly associated with CHD, polydactyly and CL/P relevant pregnancy. Mothers with higher parity might have lower risk of equinovarus occurrence in offsprings.
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