Evidence map›Paper›PMID 24282403›Full record

ArticleFrontiers in aging neuroscience2013

Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging.

Sandra B Chapman, Sina Aslan, Jeffrey S Spence, Laura F Defina, Molly W Keebler, Nyaz Didehbani, Hanzhang Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 15 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 15 syntheses or guidelines pooled it, 377 citations in OpenAlex.

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  17. One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sandra B ChapmanCenter for BrainHealth®, The University of Texas at Dallas Dallas, TX, USA.
Sina Aslan
Jeffrey S Spence
Laura F Defina
Molly W Keebler
Nyaz Didehbani
Hanzhang Lu
The University of Texas at Dallas · USAdvance (Japan) · JPCooper Institute · USSouthwestern Medical Center · US

Funding

Modulation of brain activity by control of the inspired airR01NS067015 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2010 to 2013
$1.5M
Brain & Cognitive Changes after Reasoning or Physical Training in Cognitively NorRC1AG035954 · NIA · UNIVERSITY OF TEXAS DALLAS · PI CHAPMAN, SANDRA BOND · 2009 to 2010
$1.0M
Cognition and cerebrovascular function across the lifespanR01AG042753 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2013 to 2015
$841k
NIA NIH HHS R01 AG042753NIA NIH HHS RC1 AG035954NINDS NIH HHS R01 NS067015
6 · The paper itself

Abstract

Physical exercise, particularly aerobic exercise, is documented as providing a low cost regimen to counter well-documented cognitive declines including memory, executive function, visuospatial skills, and processing speed in normally aging adults. Prior aging studies focused largely on the effects of medium to long term (>6 months) exercise training; however, the shorter term effects have not been studied. In the present study, we examined changes in brain blood flow, cognition, and fitness in 37 cognitively healthy sedentary adults (57-75 years of age) who were randomized into physical training or a wait-list control group. The physical training group received supervised aerobic exercise for 3 sessions per week 1 h each for 12 weeks. Participants' cognitive, cardiovascular fitness and resting cerebral blood flow (CBF) were assessed at baseline (T1), mid (T2), and post-training (T3). We found higher resting CBF in the anterior cingulate region in the physical training group as compared to the control group from T1 to T3. Cognitive gains were manifested in the exercise group's improved immediate and delayed memory performance from T1 to T3 which also showed a significant positive association with increases in both left and right hippocampal CBF identified earlier in the time course at T2. Additionally, the two cardiovascular parameters, VO2 max and rating of perceived exertion (RPE) showed gains, compared to the control group. These data suggest that even shorter term aerobic exercise can facilitate neuroplasticity to reduce both the biological and cognitive consequences of aging to benefit brain health in sedentary adults.

Indexed as

agingCBFexercisememoryMRI

Identifiers

PMID24282403
PMCPMC3825180
OpenAlexW2135810292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.