ArticleWorld journal of gastroenterology2013
Is early limited surgery associated with a more benign disease course in Crohn's disease?
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02716454 (Early Surgery Versus Conservative Treatment in Patients With Ileocaecal Crohn's Disease - Prospective Randomized Study), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Surgery Versus Conservative Treatment in Patients With Ileocaecal Crohn's Disease - Prospective Randomized Study
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- EARLY ILEOCECAL RESECTION IN CROHN'S DISEASE: A SYSTEMATIC REVIEW.Arquivos de gastroenterologia · 2026Pooled it
- Meta-analysis of early bowel resection versus initial medical therapy in patient's with ileocolonic Crohn's disease.International journal of colorectal disease · 2020Pooled it
- Trial
- The patient and clinician perspective on 'early' bowel resection for terminal ileal Crohn's disease (EBRIC): protocol for a multicentre mixed-methods study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Surgery time for stenosed Crohn's disease: Case report.International journal of surgery case reports · 2025Article
- Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease.World journal of gastrointestinal surgery · 2024Article
- Crohn's disease and clinical management today: How it does?World journal of methodology · 2023Review
- Stricturing Crohn's disease: what is the role of endoscopic stenting? A systematic review.Clinical endoscopy · 2023Article
- Impact of timing of primary ileocecal resection on prognosis in patients with Crohn's disease.BJS open · 2023Article
- Fibro-Stenosing Crohn's Disease: What Is New and What Is Next?Journal of clinical medicine · 2023Review
- Late is too late? Surgical timing and postoperative complications after primary ileocolic resection for Crohn's disease.International journal of colorectal disease · 2022Article
- Revisiting fibrosis in inflammatory bowel disease: the gut thickens.Nature reviews. Gastroenterology & hepatology · 2022Review
- Early Laparoscopic Ileal Resection for Localized Ileocecal Crohn's Disease: Hard Sell or a Revolutionary New Norm?Inflammatory intestinal diseases · 2022Review
- Surgery for Crohn's disease: upfront or last resort?Gastroenterology report · 2022Review
- The Revival of Surgery in Crohn's Disease-Early Intestinal Resection as a Reasonable Alternative in Localized Ileitis.Biomedicines · 2021Review
- Prevention and Treatment of Stricturing Crohn's Disease - Perspectives and Challenges.Expert review of gastroenterology & hepatology · 2021Review
- Early Ileocecal Resection Is an Effective Therapy in Isolated Crohn's Disease.Journal of clinical medicine · 2021Article
- [Terminal ileitis in Crohn's disease-Is primary surgery the better treatment?]Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- Fibrostenotic strictures in Crohn's disease.Intestinal research · 2020Review
- Natural history, diagnosis and treatment approach to fibrostenosing Crohn's disease.United European gastroenterology journal · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze the difference in disease course and need for surgery in patients with Crohn's disease (CD).
methodsData of 506 patients with incident CD were analyzed (age at diagnosis: 31.5 ± 13.8 years). Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database, which includes incident CD patients diagnosed between January 1, 1977 and December 31, 2008. Follow-up data were collected until December 31, 2009. All patients included had at least 1 year of follow-up available. Patients with indeterminate colitis at diagnosis were excluded from the analysis.
resultsOverall, 73 patients (14.4%) required resective surgery within 1 year of diagnosis. Steroid exposure and need for biological therapy were lower in patients with early limited surgery (P < 0.001 and P = 0.09). In addition, surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores (P < 0.001, HR = 0.23). The need for reoperation was also lower in patients with early limited resective surgery (P = 0.038, HR = 0.42) in a Kaplan-Meier and multivariate Cox regression (P = 0.04) analysis. However, this advantage was not observed after matching on propensity scores (P(Logrank) = 0.656, P(Breslow) = 0.498).
conclusionLong-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery, but reoperation rates did not differ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.