Evidence map›Paper›PMID 24282355›Full record

ReviewWorld journal of gastroenterology2013

Use of exclusive enteral nutrition in adults with Crohn's disease: a review.

Catherine L Wall, Andrew S Day, Richard B Gearry

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05606419 (The Crohn's Disease Exclusion Diet With Early Dairy Introduction vs Partial Enteral Nutrition), which is not on this map. Cited by 90 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 8 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05606419 nasuspendednot on this mapstarted 2024, after this paper: background citation

The Crohn's Disease Exclusion Diet With Early Dairy Introduction vs Partial Enteral Nutrition (CD-EDEN) in Adult Patients With Crohn's Disease

TypeinterventionalSponsorEvangelismos HospitalRan2024 to 2026Enrolled44ConditionsCrohn DiseaseArmsCDED+PEN, CDED+dairy
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 8 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
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  19. Host-pathobiont interactions in Crohn's disease.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Catherine L WallCatherine L Wall, Andrew S Day, Department of Paediatrics, University of Otago, Christchurch 8140, New Zealand.
Andrew S Day
Richard B Gearry
University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exclusive enteral nutrition (EEN) is well-established as a first line therapy instead of corticosteroid (CS) therapy to treat active Crohn's disease (CD) in children. It also has been shown to have benefits over and above induction of disease remission in paediatric populations. However, other than in Japanese populations, this intervention is not routinely utilised in adults. To investigate potential reasons for variation in response between adult studies of EEN and CS therapy. The Ovid database was searched over a 6-mo period. Articles directly comparing EEN and CS therapy in adults were included. Eleven articles were identified. EEN therapy remission rates varied considerably. Poor compliance with EEN therapy due to unpalatable formula was an issue in half of the studies. Remission rates of studies that only included patients with previously untreated/new CD were higher than studies including patients with both existing and new disease. There was limited evidence to determine if disease location, duration of disease or age of diagnosis affected EEN therapy outcomes. There is some evidence to support the use of EEN as a treatment option for a select group of adults, namely those motivated to adhere to an EEN regimen and possibly those newly diagnosed with CD. In addition, the use of more palatable formulas could improve treatment compliance.

Indexed as

Enteral NutritionAdrenal Cortex HormonesAdultAge FactorsAnti-Inflammatory AgentsCrohn DiseaseGastrointestinal AgentsHumansMiddle AgedNutritional StatusPatient ComplianceRemission InductionTime FactorsTreatment OutcomeYoung AdultAdrenal Cortex HormonesAnti-Inflammatory AgentsGastrointestinal AgentsAdultsCrohn’s diseaseExclusive enteral nutrition

Identifiers

PMID24282355
PMCPMC3837264
OpenAlexW2076777330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.