ArticleProceedings of the National Academy of Sciences of the United States of America2013
Rubella virus capsid protein structure and its role in virus assembly and infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Target-Based Antiviral Drug Development Against Human Respiratory Viruses.Pathogens (Basel, Switzerland) · 2026Review
- A self-amplifying RNA vector based on rubella virus for mRNA therapeutics and vaccine applications.Molecular therapy. Nucleic acids · 2026Article
- Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA.BMC biotechnology · 2025Article
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- Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles.Archives of microbiology · 2023Review
- Exogenous Rubella Virus Capsid Proteins Enhance Virus Genome Replication.Pathogens (Basel, Switzerland) · 2022Article
- Revisiting Rustrela Virus: New Cases of Encephalitis and a Solution to the Capsid Enigma.Microbiology spectrum · 2022Article
- Design of a chimaeric antigen and its use in the detection of IgG antibodies against rubella virus.Virology journal · 2022Article
- Molecular and Structural Insights into the Life Cycle of Rubella Virus.Journal of virology · 2021Review
- The Enigmatic Capsid Protein of an Encephalitic Rubivirus.Journal of virology · 2021Article
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- Molecular Application of Aptamers in the Diagnosis and Treatment of Cancer and Communicable Diseases.Pharmaceuticals (Basel, Switzerland) · 2018Review
- A novel Ffu fusion system for secretory expression of heterologous proteins in Escherichia coli.Microbial cell factories · 2017Article
- Assembly, maturation and three-dimensional helical structure of the teratogenic rubella virus.PLoS pathogens · 2017Article
- Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome.PLoS neglected tropical diseases · 2016Review
- Calcium-Dependent Rubella Virus Fusion Occurs in Early Endosomes.Journal of virology · 2016Article
- Standardization of Assays That Detect Anti-Rubella Virus IgG Antibodies.Clinical microbiology reviews · 2016Review
- Rubella virus: first calcium-requiring viral fusion protein.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
Rubella virus (RV) is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, RV infection leads to severe damage in fetuses. Despite its medical importance, compared with the related alphaviruses, very little is known about the structure of RV. The RV capsid protein is an essential structural component of virions as well as a key factor in virus-host interactions. Here we describe three crystal structures of the structural domain of the RV capsid protein. The polypeptide fold of the RV capsid protomer has not been observed previously. Combining the atomic structure of the RV capsid protein with the cryoelectron tomograms of RV particles established a low-resolution structure of the virion. Mutational studies based on this structure confirmed the role of amino acid residues in the capsid that function in the assembly of infectious virions.
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Registered trials
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