ArticleProceedings of the National Academy of Sciences of the United States of America2013
Sleep spindles are generated in the absence of T-type calcium channel-mediated low-threshold burst firing of thalamocortical neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 66 citations in OpenAlex.
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Article
- Acute Sleep Deprivation Suppresses Sleep Spindles in Mice.Nature and science of sleep · 2025Article
- Voltage Gated Ion Channels and Sleep.The Journal of membrane biology · 2024Review
- Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges.eNeuro · 2024Article
- GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol- and isoflurane-mediated general anesthesia.CNS neuroscience & therapeutics · 2024Article
- Circuits and components of delta wave regulation.Brain research bulletin · 2022Review
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.ACS pharmacology & translational science · 2022Article
- Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics.International journal of molecular sciences · 2022Review
- The T-type calcium channel isoform CaBritish journal of anaesthesia · 2021Article
- Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.Scientific reports · 2020Article
- Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice.Scientific reports · 2019Article
- Single unit activities recorded in the thalamus and the overlying parietal cortex of subjects affected by disorders of consciousness.PloS one · 2018Article
- Stimulus-induced transitions between spike-wave discharges and spindles with the modulation of thalamic reticular nucleus.Journal of computational neuroscience · 2017Article
- An unaware agenda: interictal consciousness impairments in epileptic patients.Neuroscience of consciousness · 2017Article
- Neural Plasticity Is Involved in Physiological Sleep, Depressive Sleep Disturbances, and Antidepressant Treatments.Neural plasticity · 2017Review
- The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.Molecular brain · 2016Article
- Timing matters: open-loop stimulation does not improve overnight consolidation of word pairs in humans.The European journal of neuroscience · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-type Ca(2+) channels in thalamocortical (TC) neurons have long been considered to play a critical role in the genesis of sleep spindles, one of several TC oscillations. A classical model for TC oscillations states that reciprocal interaction between synaptically connected GABAergic thalamic reticular nucleus (TRN) neurons and glutamatergic TC neurons generates oscillations through T-type channel-mediated low-threshold burst firings of neurons in the two nuclei. These oscillations are then transmitted from TC neurons to cortical neurons, contributing to the network of TC oscillations. Unexpectedly, however, we found that both WT and KO mice for CaV3.1, the gene for T-type Ca(2+) channels in TC neurons, exhibit typical waxing-and-waning sleep spindle waves at a similar occurrence and with similar amplitudes and episode durations during non-rapid eye movement sleep. Single-unit recording in parallel with electroencephalography in vivo confirmed a complete lack of burst firing in the mutant TC neurons. Of particular interest, the tonic spike frequency in TC neurons was significantly increased during spindle periods compared with nonspindle periods in both genotypes. In contrast, no significant change in burst firing frequency between spindle and nonspindle periods was noted in the WT mice. Furthermore, spindle-like oscillations were readily generated within intrathalamic circuits composed solely of TRN and TC neurons in vitro in both the KO mutant and WT mice. Our findings call into question the essential role of low-threshold burst firings in TC neurons and suggest that tonic firing is important for the generation and propagation of spindle oscillations in the TC circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.