ArticleeLife2013
Developmental lineage priming in Dictyostelium by heterogeneous Ras activation.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- Imaging developmental cell cycles.Biophysical journal · 2021Review
- Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology.BMC biology · 2021Article
- Evolution of Reproductive Division of Labor - Lessons Learned From the Social AmoebaFrontiers in cell and developmental biology · 2021Article
- Coordination between patterning and morphogenesis ensures robustness during mouse development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Conditional expression explains molecular evolution of social genes in a microbe.Nature communications · 2019Article
- Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning.Developmental cell · 2018Article
- Strategic investment explains patterns of cooperation and cheating in a microbe.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Eat Prey, Live:Frontiers in immunology · 2017Review
- Genetic control of morphogenesis in Dictyostelium.Developmental biology · 2015Review
- Evolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system.Cell and tissue research · 2015Review
- Survival of the fattest.eLife · 2013Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
In cell culture, genetically identical cells often exhibit heterogeneous behavior, with only 'lineage primed' cells responding to differentiation inducing signals. It has recently been proposed that such heterogeneity exists during normal embryonic development to allow position independent patterning based on 'salt and pepper' differentiation and sorting out. However, the molecular basis of lineage priming and how it leads to reproducible cell type proportioning are poorly understood. To address this, we employed a novel forward genetic approach in the model organism Dictyostelium discoideum. These studies reveal that the Ras-GTPase regulator gefE is required for normal lineage priming and salt and pepper differentiation. This is because Ras-GTPase activity sets the intrinsic response threshold to lineage specific differentiation signals. Importantly, we show that although gefE expression is uniform, transcription of its target, rasD, is both heterogeneous and dynamic, thus providing a novel mechanism for heterogeneity generation and position-independent differentiation. DOI: http://dx.doi.org/10.7554/eLife.01067.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.